IMGT Repertoire (IG and TR)

Collier de Perles: human (Homo sapiens) CD2

CD58*01 C-LIKE (Y14780)

Polymorphisms:

  • CD2*01 (AF105261): D 1, K 2, E 4, R 7, L 8, Q 9, G 10, Q 11, G 12, K 13, Q 18, V 19, A 20, S 22, L 24, S 26, R 29, D 30, G 31, N 36, V 37, S 38, Y 37, A 40, W 41, R 43, G 44, S 45, L 45.2, I 45.3, Q 77, T 78, A 79, G 80, Y 88, L 89, D 90, E 91, E 92, V 93, D 94, I 95, N 96, G 98, T 99, H 100, T 101, Y 102, T 103, N 105, V 106, S 107, P 109, W 116, H 119, T 120, L 121, N 122, L 123, T 124, Q 125, D 126

On one layer

On two layers

Colors are according to IMGT Color menu for sequence alignments and Color menu for CDR-IMGT

Legend:
  • Amino acids are shown in the one-letter abbreviation.
  • Hydrophobic amino acids (hydropathy index with positive value) and Tryptophan (W) found at a given position in more than 50% of analysed IG and TR sequences are shown in blue.
  • All Proline (P) are shown in yellow.
  • Missing positions in IMGT Colliers de Perles based on 3D structures may be due to incomplete experimental data.
  • Arrows indicate the direction of the beta sheets and their different designations in 3D structures. This information has to be used carefully if not supported by experimental data.
  • The positions 26, 39 and 104 are shown in squares by homology with the corresponding positions in the V-REGIONs. Positions 45 and 77 which delimit the characteristic "CD" strand of the C-DOMAINs, and position 118 which corresponds structurally to J-PHE or J-TRP of the J-REGION, are also shown in squares.
  • Hatched circles or squares correspond to missing positions according to the IMGT unique numbering for C-DOMAINs (Lefranc et al. 2005 PMID: 15572068 PDF).
  • In green, position of amino acid changes involved in allotype polymorphism.
  • Strands of the beta-pleated sheet localized at the interface between domains are shown in bold.
  • The hinge six amino acids which belongs to the same exon as the CH2 domain are not shown.
  • The CHS region is not shown.
See also:
Created:
23/02/2011
Last updated:
Wednesday, 23-Oct-2024 09:53:41 CEST
Authors:
François Ehrenmann, Chantal Ginestoux and Patrice Duroux