Colors are according to IMGT Color menu for sequence alignments and Color menu for CDR-IMGT

• Amino acids are shown in the one-letter abbreviation.
• Hydrophobic amino acids (hydropathy index with positive value) and Tryptophan (W) found at a given position in more than 50% of analysed IG and TR sequences are shown in blue.
• All Proline (P) are shown in yellow.
• Missing positions in IMGT Colliers de Perles based on 3D structures may be due to incomplete experimental data.
• Arrows indicate the direction of the beta sheets and their different designations in 3D structures. This information has to be used carefully if not supported by experimental data.
• The positions 26, 39 and 104 are shown in squares by homology with the corresponding positions in the V-REGIONs. Positions 45 and 77 which delimit the characteristic "CD" strand of the C-DOMAINs, and position 118 which corresponds structurally to J-PHE or J-TRP of the J-REGION, are also shown in squares.
• Hatched circles or squares correspond to missing positions according to the IMGT unique numbering for C-DOMAINs (Lefranc et al. 2005 PMID: 15572068 ).
• In green, position of amino acid changes involved in allotype polymorphism.
• Strands of the beta-pleated sheet localized at the interface between domains are shown in bold.
• The hinge six amino acids which belongs to the same exon as the CH2 domain are not shown.
• The CHS region is not shown.