Translocations and inversions: Human Overview

Click here to see: Part 2 - Chromosomal localizations of the genes (other than IG and TR) involved in the translocations
Part 3 - Chromosomal localizations of the human IG and TR loci
Part 4 - Clinical entities with IG and TR translocations

Part 1 - Genes involved in the immunoglobulin (IG) and T cell receptor (TR) translocations

Genes (1)
(other than IG and TR)		 Gene definition (1) Chromosomal
localization		 OMIM Aliases (1) Withdrawn
symbols (1)		 Translocations IG and TR
involved loci
BCL2 B cell CLL/lymphoma 2 18q21.3 151430     t(2;18) (p12;q21) IGK
t(14;18)(q32;q21) IGH
t(18;22) (q21;q11) IGL
BCL3 B cell CLL/lymphoma 3 19q13.1-q13.2 109560   BCL4 t(14;19)(q32;q13.1) IGH
BCL6 B cell CLL/lymphoma 6 (zinc finger protein 51) 3q27 109565 BCL5, LAZ3 ZNF51 t(2;3)(p11;q27)IGK
t(3;14)(q27;q32) IGH
t(3;22)(q27;q11) IGL
BCL9 B cell CLL/lymphoma 9 1q21       t(1;22)(q21;q11) IGL
BCL10 B cell CLL/lymphoma 10 1p22 603517 c-EIO, CARMEN,
CIPER, CLAP,
mE10		   t(1;14)(p22;q32) IGH
BCL11A B cell CLL/lymphoma 11A (zinc finger protein) 2p13   EVI9   t(2;14)(p13;q32) IGH
CCND1 cyclin D1 (PRAD1: parathyroid adenomatosis 1) 11q13.3 151400 BCL1,PRAD1   t(11;14)(q13;q32) IGH
CCND3 cyclin D3 6p21       t(6;14)(p21;q32) IGH
FGFR3 fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) 4p16.3 134934 CEK2 ACH t(4;14)(p16;q32) IGH
IL3 interleukin 3 (colony-stimulating factor, multiple) 5q23-q31 147740     t(5;14)(q31;q32) IGH
LCK lymphocyte-specific protein tyrosine kinase 1p34.3       t(1;7)(p34;q34) TRB
LMO1 LIM domain only 1 (rhombotin 1) 11p15 186921 TTG1 RBTN1 t(11;14)(p15;q11) TRD
LMO2 LIM domain only 2 (rhombotin-like 1) 11p13 180385 RBTN2, RHOM2,
TTG2		 RBTNL1 t(7;11)(q34;p13) TRB
t(11;14)(p13;q11) TRA
t(11;14)(p13;q11) TRD
LYL1 lymphoblastic leukemia derived sequence 1 19p13.2 151440     t(7;19)(q34;p13) TRB
MTCP1 mature T cell proliferation 1 Xq28       t(X;14)(q28;q11) TRA
MUC1 mucin 1, transmembrane 1q21       t(1;14)(q21;q32) IGH
MYC v-myc avian myelocytomatosis viral oncogene
homolog		 8q24 190080     t(2;8)(p11;q24) IGK
t(8;14)(q24;q11) TRA
t(8;14)(q24;q11) TRD
t(8;14)(q24;q32) IGH
t(8;22)(q24;q11) IGL
NFKB2 nuclear factor of kappa light polypeptide
gene enhancer in B-cells 2 (p49/p100)		 10q24 164012 LYT-10   t(10;14)(q24;q32) IGH
NOTCH1 Notch (Drosophilia) homolog1
(translocation-associated)		 9q34.3 190198   TAN1 t(7;9)(q34;q34) TRB
PAX5 paired box gene 5
(B-cell lineage specific activator protein)		 9p13 167414 BSAP   t(9;14)(p13;q32) IGH
TAL1 T cell acute lymphocytic leukemia 1 1p32 187040 SCL TCL5 t(1;7)(p32;q34) TRB
t(1;14)(p32;q11) TRA
t(1;14)(p32;q11) TRD
TAL2 T cell acute lymphocytic leukemia 2 9q32 186855     t(7;9)(q34;q32) TRB
TCL1A T cell leukemia/lymphoma 1A 14q32.1 186960 TCL1   t(14;14)(q11;q32) TRA
TLX1 T-cell leukemia, homeobox 1 10q24 186770 TCL3, HOX11   t(7;10)(q34;q24) TRB
t(10;14)(q24;q11) TRA
t(10;14)(q24;q11) TRD

IMGT note:
(1) Gene symbol, gene definition, aliases and withdrawn symbols are according to the Human Genome Organization Nomenclature Committee (HGNC).

Created: 23/11/2000
Last updated: 02/10/2025 13:10
Author:Marie-Paule Lefranc
Editors: Sandrine Béranger and Céline Protat