Citing IMGT dynamic tools: Sanou G., Zeitoun G. et al. IMGT® at scale: FAIR, Dynamic and Automated Tools for Immune Locus Analysis, Nucleic Acids Research. 2025;,gkaf1024. doi: 10.1093/nar/gkaf1024 (Free Article) PMID: 41091930.
Program version: v. 

Add information about removed genes/alleles.
May 15th, 2025.

Add the possibility to obtain a gene table per strain (for mouse now and for other species later) and allotypes/isotypes for human.
September 25th, 2024.

Bibliographical references in alphabetic order, small design changes and addition of "NL" for non-localized gene.
June 14th, 2024.

Addition of 'Score for IMGT allele confirmation' as well as NCBI TPA accession numbers.
September 20th, 2023.

Implementation of the dynamic gene table.

Gene table legend:

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene, when the data have been confirmed by several studies.

Functionality is shown in parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.

IMGT allele confirmation: A scoring system is employed to indicate the number of IMGT/LIGM-DB reference sequences and other sequences from the literature in which an IG or TR gene allele has been identified and annotated.

Removed genes/alleles
If a gene/allele existence or name has to be changed, the old name or gene/allele would be deleted and its name won't be reused. They are kept in the gene table for historical reasons.
A single star ()
indicates that an IG or TR gene allele is annotated in the reference sequence only.
Two stars ()
indicate that an IG or TR gene allele is annotated in its reference sequence and in one sequence from the literature.
Three stars ()
indicate that an IG or TR gene allele is annotated in its reference sequence and in at least two sequences from the literature.
In the Excel file, the stars are represented by the plus symbol (+).

Click on:
  • IMGT gene name to get the corresponding IMGT/GENE-DB entry (link).
  • IMGT allele name to see the corresponding Alignments of alleles (link).
  • Accession number to get the corresponding IMGT/LIGM-DB entry (link).
  • MAP: mapped sequences. Click to access GENE-DB «LOCALIZATION IN GENOME ASSEMBLIES» (link).
  • [number] to access the corresponding IMGT reference (popover).
  • (number) to see the corresponding IMGT note (popover).
Options:
  • You can show/hide columns (), download data () or put the table in fullscreen () using buttons.
See also (IMGT Scientific chart):
Select a species and a IMGT group to get the gene table:
Only IMGT available species/group are shown in the drop-down list.
The gene table can take several seconds to appear, please be patient.

Rearranged (R) and transcribed (T) information are from Assignment of rearranged cDNAs and gDNAs to germline genes: Human TRAV.

Since the TRD locus is embedded in the TRA locus (The T cell receptor FactsBook), a few TRAV genes have been found rearranged, not only as expected to TRAJ but also to TRDD-TRDJ genes. The first five Homo sapiens TRAV genes found in that case received the designation TRAV/DV (this does not exclude that other TRAV genes may be found occasionally rearranged to TRDD-TRDJ). They include Homo sapiens TRAV14/DV4, TRAV29/DV5, TRAV23/DV6, TRAV36/DV7 and TRAV38-2/DV8 genes.

The "invariant" TR alpha chain of the human CD161+ T cells which recognize CD1d results f rom the TRAV10-TRAJ18 (previously Valpha24-JalphaQ) rearrangement. CD161 is expressed by ~15% of human T cells but only a very small fraction of these CD161+ T cells are invariant NK T cells (<0,1 % of total T cells and <1% of CD161+ T cells in most donors) [Exley, M.A. et al., Current Protocols in Immunology, Wiley, J. and Sons, New York, 14, 14.11.1-14.11.13 (2002)].

Gene table of human (Homo sapiens) TRAV IMGT group:
IMGT sub­groupIMGT gene nameIMGT allele nameScore for
IMGT allele
confirmation		FctChromosomosal
localization		R T PrIMGT/LIGM-DB reference sequencesIMGT/LIGM-DB sequences from the literature
Clone namesAccession
numbers		Positions
in the sequence
(L-V-GENE-UNIT)
or V-REGION (*)		Secondary
accession
numbers		Clone namesAccession
numbers		Positions
in the sequence
(L-V-GENE-UNIT)
or V-REGION (*)
TRAV1TRAV1-1 TRAV1-1*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V1S1 AE000658 [5,7,21] MAP 127701-128403 CM000676.2 IMGT000024 [13,23] 10001-10703
CM089104.1 IMGT000290 [26] 9612-10314
M12070 [2] #g 53-322 *
TRAV1TRAV1-1 TRAV1-1*02 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 Valpha7.1 X04939 [47] #c 52-320 * AV7S1 L11161 [8] (22) ° 387->625 *
TRAV1TRAV1-2 TRAV1-2*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V1S2 AE000658 [5,7,21] 148837-149489 CM089104.1 IMGT000290 [26] 30762-31414
Valpha7 X58744 [36] (23) #c 120->386 *
TRAV1TRAV1-2 TRAV1-2*02 [F] 14q11.2 AV7S2 U32544 [6] (24) ° 302->477 *
TRAV1TRAV1-2 TRAV1-2*03 F 14q11.2 CM000676.2 IMGT000024 [13,23] MAP 31070-31722
TRAV2TRAV2 TRAV2*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V2S1 AE000658 [5,7,21] MAP 218198-218749 CM000676.2 IMGT000024 [13,23] 100428-100979
CM089104.1 IMGT000290 [26] 100116-100667
AV11S1 U32522 [6] (25) ° 241->401 *
Valpha11.1 X04936 [47] #c 76-337 *
TRAV2TRAV2 TRAV2*02 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 Valpha11.1 M17659 [20] #c 53-316 *
TRAV3TRAV3 TRAV3*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V3S1 AE000658 [5,7,21] MAP 229780-230251 CM000676.2 IMGT000024 [13,23] 111986-112457
CM089104.1 IMGT000290 [26] 111685-112156
Valpha1.6 M17651 [20] #c 28-311 *
AV16S1 U32525 [6] (26) ° 138->396 *
TRAV3TRAV3 TRAV3*02 (P) (1) 14q11.2
R αT αPr αR δT δPr δ
++
 Valpha16.1 M27377 [19] #c 58-341 *
TRAV4TRAV4 TRAV4*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V4S1 AE000658 [5,7,21] MAP 242145-242947 CM000676.2 IMGT000024 [13,23] 124316-125118
CM089104.1 IMGT000290 [26] 124039-124841
Valpha16.1 M17663 [20] #c 52-318 *
AV20S1 U32529 [6] (27) 378->526 *
TRAV5TRAV5 TRAV5*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V5S1 AE000659 [5,7,21] MAP 4647-5201 CM000676.2 IMGT000024 [13,23] 137287-137841
CM089104.1 IMGT000290 [26] 137008-137562
Valpha15.1 M27376 [19] #c 52-328 *
TRAV6TRAV6 TRAV6*01 F 14q11.2 V6S1 AE000659 [5,7,21] 23966-24532
TRAV6TRAV6 TRAV6*02 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 Valpha5 X58747 [36] (23) #c 128->400 *
TRAV6TRAV6 TRAV6*03 [F] 14q11.2
R αT αPr αR δT δPr δ
++
 AV5S1 Z49060 [16] (28) ° <1->249 *
TRAV6TRAV6 TRAV6*04 [F] 14q11.2 AV5S1 Y10409 [17] (28) ° <1->249 *
TRAV6TRAV6 TRAV6*05 [F] 14q11.2 AV5S1 Y10410 [17] (28) ° <1->249 *
TRAV6TRAV6 TRAV6*06 [F] 14q11.2 AV5S1 U32542 [6] (29) ° 174->390 *
TRAV6TRAV6 TRAV6*07 F 14q11.2 CM000676.2 IMGT000024 [13,23] MAP 156650-157216 CM089104.1 IMGT000290 [26] 156324-156890
TRAV7TRAV7 TRAV7*01 F 14q11.2 V7S1 AE000659 [5,7,21] MAP 38383-38932 CM000676.2 IMGT000024 [13,23] 171090-171639
CM089104.1 IMGT000290 [26] 170746-171295
TRAV8TRAV8-1 TRAV8-1*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V8S1 AE000659 [5,7,21] MAP 52764-53270 CM000676.2 IMGT000024 [13,23] 185516-186022
CM089104.1 IMGT000290 [26] 185163-185669
Valpha1.1 X04949 [47] #c 58-340 *
TRAV8TRAV8-1 TRAV8-1*02 [F] 14q11.2 AV1S1 U32520 [6] (30) ° 122->371 *
TRAV8TRAV8-2 TRAV8-2*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V8S2 AE000659 [5,7,21] 102117-102614 CM089104.1 IMGT000290 [26] 234507-235004
TRAV8TRAV8-2 TRAV8-2*02 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 Valpha1.5 M17650 [20] #c 16-295 *
TRAV8TRAV8-2 TRAV8-2*03 F 14q11.2 CM000676.2 IMGT000024 [13,23] MAP 234859-235356
TRAV8TRAV8-3 TRAV8-3*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V8S3 AE000659 [5,7,21] MAP 107908-108395 CM000676.2 IMGT000024 [13,23] 240655-241142
TRAV8TRAV8-3 TRAV8-3*02 F 14q11.2
R αT αPr αR δT δPr δ
++
 CM089104.1 IMGT000290 [26] 240289-240776 Valpha1.4 M35617 [1] #g 177-456 *
TRAV8TRAV8-3 TRAV8-3*03 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 Valpha1.n1 L06885 [37] (23) #c 25->300 *
TRAV8TRAV8-4 TRAV8-4*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V8S4 AE000659 [5,7,21] MAP 149914-150421 CM000676.2 IMGT000024 [13,23] 282658-283165
CM089104.1 IMGT000290 [26] 282319-282826
X02592 [33] #c 186-469 *
TRAV8TRAV8-4 TRAV8-4*02 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 M12423 [44] #c 227-510 *
TRAV8TRAV8-4 TRAV8-4*03 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 AV1.2a D13077 [30] (23) #c 58->333 *
TRAV8TRAV8-4 TRAV8-4*04 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 M12959 [33] #c 194-477 *
TRAV8TRAV8-4 TRAV8-4*05 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 Valpha1.2 X63455 [14] #c 147-430 *
TRAV8TRAV8-4 TRAV8-4*06 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 K02777 [10] (31) #c <1-218 *
TRAV8TRAV8-4 TRAV8-4*07 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 Valpha1.2 M17665 [20] (32) #c <1-197 *
TRAV8TRAV8-5 TRAV8-5*01 P (2) 14q11.2 V8S5 AE000659 [5,7,21] MAP 158430-159989 CM000676.2 IMGT000024 [13,23] (33) 291339->291422 *
CM089104.1 IMGT000290 [26] 290999-291082 *
TRAV8TRAV8-6 TRAV8-6*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 ValphapY14.2 X02850 [46] MAP 44-523 CM000676.2 IMGT000024 [13,23] 366776-367255
CM089104.1 IMGT000290 [26] 366441-366920
TRAV8TRAV8-6 TRAV8-6*02 F 14q11.2
R αT αPr αR δT δPr δ
++
 V8S6 AE000659 [5,7,21] 234092-234571 Valpha1.3 M86361 [22] #c 278-558 *
TRAV8TRAV8-6-1 TRAV8-6-1*01 P (3) 14q11.2 AE000660 [5,7,21] MAP 70134-70651 CM000676.2 IMGT000024 [13,23] 453935-454452
CM089104.1 IMGT000290 [26] 453620-454137
TRAV8TRAV8-7 TRAV8-7*01 P (4) 14q11.2 V8S7 AE000660 [5,7,21] 136547-137067 CM089104.1 IMGT000290 [26] 520339-520859
TRAV8TRAV8-7 TRAV8-7*02 P (5) 14q11.2 U76492 [42] ° MAP 1-521 DQ097953 338-858
CM000676.2 IMGT000024 [13,23] 520650-521170
TRAV9TRAV9-1 TRAV9-1*01 F 14q11.2 V9S1 AE000659 [5,7,21] MAP 66847-67361 CM000676.2 IMGT000024 [13,23] 199599-200113
CM089104.1 IMGT000290 [26] 199255-199769
TRAV9TRAV9-2 TRAV9-2*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V9S2 AE000659 [5,7,21] 196542-197060 AV22.1a D13072 [30] #c 58-332 *
TRAV9TRAV9-2 TRAV9-2*02 F 14q11.2
R αT αPr αR δT δPr δ
++
 CM000676.2 IMGT000024 [13,23] MAP 329281-329793 CM089104.1 IMGT000290 [26] 328934-329446
AV22S1 U32530 [6] (34) ° 148->404 *
Valpha22 X58745 [36] (23) #c 111->383 *
TRAV9TRAV9-2 TRAV9-2*03 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 Valpha22n1 L06881 [37] (23) #c 58->330 *
TRAV9TRAV9-2 TRAV9-2*04 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 Valpha22n2 L06882 [37] (23) #c 58-330 *
TRAV10TRAV10 TRAV10*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V10S1 AE000659 [5,7,21] 80845-81451 CM089104.1 IMGT000290 [26] 213247-213853
AV24S1 U32532 [6] (35) 251->487 *
Valphaw24 X58737 [36] (23) #c 99->371 *
TRAV10TRAV10 TRAV10*02 F 14q11.2 CM000676.2 IMGT000024 [13,23] MAP 213605-214211
TRAV11TRAV11 TRAV11*01 P (6) 14q11.2 V11S1 AE000659 [5,7,21] MAP 84865-85436 CM000676.2 IMGT000024 [13,23] 217636-218207
CM089104.1 IMGT000290 [26] 217270-217841
TRAV11TRAV11-1 TRAV11-1*01 P (7) 14q11.2 V11S1 AE000659 [5,7,21] MAP 133585-134152 CM000676.2 IMGT000024 [13,23] 266327-266894
CM089104.1 IMGT000290 [26] 265993-266560
TRAV12TRAV12-1 TRAV12-1*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V12S1 AE000659 [5,7,21] MAP 96598-97168 AV2.5a D13078 [30] (23) #c 64->330 *
CM000676.2 IMGT000024 [13,23] 229337-229910
CM089104.1 IMGT000290 [26] 228988-229558
TRAV12TRAV12-1 TRAV12-1*02 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 Valpha2.3 M17657 [20] #c 67-340 *
TRAV12TRAV12-2 TRAV12-2*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V12S2 AE000659 [5,7,21] MAP 143315-143894 CM000676.2 IMGT000024 [13,23] 276056-276638
CM089104.1 IMGT000290 [26] 275719-276298
Valpha2.2 M27369 [19] (36) #c 1-245 *
TRAV12TRAV12-2 TRAV12-2*02 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 Valpha2.1 M81774 [39,47] #c 67-339 * AV2S1 L11159 [8] (37) ° 267->486 *
TRAV12TRAV12-2 TRAV12-2*03 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 Valpha2.1 X04946 [47] (36) #c <1-252 *
TRAV12TRAV12-3 TRAV12-3*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V12S3 AE000659 [5,7,21] MAP 220909-221502 CM000676.2 IMGT000024 [13,23] 353604-354197
CM089104.1 IMGT000290 [26] 353257-353850
AV2S4 U32538 [6] (38) ° 181->377 *
X06193 [27] 21-540
TRAV12TRAV12-3 TRAV12-3*02 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 Valpha2.2 M17656 [20] #c 67-343 *
TRAV13TRAV13-1 TRAV13-1*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V13S1 AE000659 [5,7,21] MAP 124216-124758 AV8.1a D13079 [30] (23) #c 58-330 *
CM000676.2 IMGT000024 [13,23] 256959-257501
CM089104.1 IMGT000290 [26] 256624-257166
M99570 [9] (39) <1->270 *
TRAV13TRAV13-1 TRAV13-1*02 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 Valpha8.1 X04954 [47] #c 58-337 *
TRAV13TRAV13-1 TRAV13-1*03 [F] 14q11.2 AV8S1 L11162 [8] (40) ° 222->455 *
TRAV13TRAV13-2 TRAV13-2*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V13S2 AE000659 [5,7,21] MAP 173606-174143 CM000676.2 IMGT000024 [13,23] 306355-306892
CM089104.1 IMGT000290 [26] 306008-306545
AV8S2 U32545 [6] (37) ° 197->419 *
Valpha8.2 X04956 [47] #c 61-337 *
TRAV13TRAV13-2 TRAV13-2*02 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 Valpha8.2 M17658 [20] #c 48-324 *
TRAV14TRAV14/DV4 TRAV14/DV4*01 F 14q11.2
R αT αPr αR δT δPr δ
++++
 M21626 [12] MAP 1-554 CM000676.2 IMGT000024 [13,23] 312235-312787
CM089104.1 IMGT000290 [26] 311888-312440
TRAV14TRAV14/DV4 TRAV14/DV4*02 F 14q11.2
R αT αPr αR δT δPr δ
++
 hADV14S1 AE000659 [5,7,21] 179487-180039 S51029 [45] (41) #c 61->349 *
TRAV14TRAV14/DV4 TRAV14/DV4*03 (F) 14q11.2
R αT αPr αR δT δPr δ
++++
 M21624 [12] #c 131-412 *
TRAV14TRAV14/DV4 TRAV14/DV4*04 [F] 14q11.2
R αT αPr αR δT δPr δ
++
 AV06S1 L09758 [34] (42) ° <1->271 *
TRAV14TRAV14-1 TRAV14-1*01 P (8) 14q11.2 AE000659 [5,7,21] 129904-130448 CM089104.1 IMGT000290 [26] 262312-262856
TRAV14TRAV14-1 TRAV14-1*02 P (8) 14q11.2 CM000676.2 IMGT000024 [13,23] MAP 262646-263190
TRAV15TRAV15 TRAV15*01 P (9) 14q11.2 V15S1 AE000659 [5,7,21] MAP 205768-206050 * CM000676.2 IMGT000024 [13,23] 338224-338789
CM089104.1 IMGT000290 [26] 337877-338442
TRAV16TRAV16 TRAV16*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V16S1 AE000659 [5,7,21] MAP 245908-246388 CM000676.2 IMGT000024 [13,23] 378593-379073
CM089104.1 IMGT000290 [26] 378258-378738
AV9S1 U32546 [6] (30) ° 165->403 *
Valpha9.1 X04942 [47] #c 58-328 *
TRAV17TRAV17 TRAV17*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V17S1 AE000660 [5,7,21] MAP 1957-2478 CM000676.2 IMGT000024 [13,23] 385783-386304
CM089104.1 IMGT000290 [26] 385448-385969
AV3S1 U32540 [6] (43) ° 165->350 *
Valpha3.1 X04955 [47] #c 61-332 *
TRAV18TRAV18 TRAV18*01 F 14q11.2 V18S1 AE000660 [5,7,21] MAP 7482-7983 CM000676.2 IMGT000024 [13,23] 391308-391809
CM089104.1 IMGT000290 [26] 390973-391474
TRAV19TRAV19 TRAV19*01 F 14q11.2
R αT αPr αR δT δPr δ
+++
 V19S1 AE000660 [5,7,21] MAP 11900-12491 CM000676.2 IMGT000024 [13,23] 395726-396317
CM089104.1 IMGT000290 [26] 395391-395982
X01403 [40] #c 58-339 *
E4 Z46641 [28] (44) #g 20->308 *
TRAV20TRAV20 TRAV20*01 F 14q11.2 V20S1 AE000660 [5,7,21] 44941-45470
TRAV20TRAV20 TRAV20*02 F 14q11.2
R αT αPr αR δT δPr δ
++
 CM000676.2 IMGT000024 [13,23] MAP 428760-429289 CM089104.1 IMGT000290 [26] 428431-428960
X68696 [29] (23) #c 131->397 *
TRAV20TRAV20 TRAV20*03 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 Valpha28.2 S60789 [41] (45) #c 79->342 *
TRAV20TRAV20 TRAV20*04 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 Valphaw30 X70305 [31] (23) #c 133->399 *
TRAV21TRAV21 TRAV21*01 F 14q11.2 V21S1 AE000660 [5,7,21] MAP 56812-57386 CM000676.2 IMGT000024 [13,23] 440618-441192
CM089104.1 IMGT000290 [26] 440301-440875
TRAV21TRAV21 TRAV21*02 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 Valphaw23 X58736 [36] (23) #c 128->400 *
TRAV22TRAV22 TRAV22*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V22S1 AE000660 [5,7,21] MAP 74985-75542 CM000676.2 IMGT000024 [13,23] 458787-459344
CM089104.1 IMGT000290 [26] 458472-459029
Valpha13.1 M27374 [19] #c 49-313 *
TRAV23TRAV23/DV6 TRAV23/DV6*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 hADV23S1 AE000660 [5,7,21] 90761-91309 CM089104.1 IMGT000290 [26] 474235-474783
Valpha13.1 M22936 [38] (46,47) <1-176 *
AV17S1 U32526 [6] (30) ° 159->405 *
Valpha17b X70309 [31] (23) #c 130-402 *
TRAV23TRAV23/DV6 TRAV23/DV6*02 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 Valpha13.1 M17660 [20] #c 85-364 * Valpha13.1 M22936 [38] (46,47) <1-176 *
TRAV23TRAV23/DV6 TRAV23/DV6*03 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 Valpha17.1-V M97704 [15] #c 145-424 * AV17S1 Z49057 [16] (48) <1->267 *
TRAV23TRAV23/DV6 TRAV23/DV6*04 [F] 14q11.2 Y10411 [17] (48) ° <1->267 *
TRAV23TRAV23/DV6 TRAV23/DV6*05 F 14q11.2 CM000676.2 IMGT000024 [13,23] MAP 474549-475097
TRAV24TRAV24 TRAV24*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V24S1 AE000660 [5,7,21] MAP 109652-110194 CM000676.2 IMGT000024 [13,23] 493440-493982
CM089104.1 IMGT000290 [26] 493121-493663
TRAV24TRAV24 TRAV24*02 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 Valpha14.1 M17661 [20] #c 64-340 *
TRAV25TRAV25 TRAV25*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V25S1 AE000660 [5,7,21] MAP 116408-117055 CM000676.2 IMGT000024 [13,23] 500520-501167
CM089104.1 IMGT000290 [26] 500199-500846
Valpha30 M64350 [4] #c 167-439 *
TRAV26TRAV26-1 TRAV26-1*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V26S1 AE000660 [5,7,21] 127517-128314 CM089104.1 IMGT000290 [26] 511309-512106
Valpha4.2 M27370 [19] #c 52-325 *
TRAV26TRAV26-1 TRAV26-1*02 F 14q11.2
R αT αPr αR δT δPr δ
++
 CM000676.2 IMGT000024 [13,23] MAP 511624-512421 Valpha4.2 M27371 [19] #c 52-325 *
AV4S2 U32541 [6] (49) 440->642 *
TRAV26TRAV26-1 TRAV26-1*03 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 Valpha4.n1 L06886 [37] (23) #c 52->318 *
TRAV26TRAV26-2 TRAV26-2*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V26S2 AE000660 [5,7,21] MAP 206509-207333 CM000676.2 IMGT000024 [13,23] 590680-591504
CM089104.1 IMGT000290 [26] 590374-591198
Valpha4.1 X04937 [47] #c 52-318 *
TRAV26TRAV26-2 TRAV26-2*02 [F] 14q11.2 AV4S1 L11160 [8] (37) ° 509->725 *
TRAV27TRAV27 TRAV27*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V27S1 AE000660 [5,7,21] 152078-152658 AV10S2 L09760 [34] (48) ° <1->264 *
AV10S1 U32521 [6] (47,50) ° 233->421 *
TRAV27TRAV27 TRAV27*02 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 AV10.1 X04957 [47] #c 55-326 *
TRAV27TRAV27 TRAV27*03 F 14q11.2
R αT αPr αR δT δPr δ
++
 CM000676.2 IMGT000024 [13,23] MAP 536189-536769 Valpha10.1a D13075 [30] (23) #c 55->324 *
AV10S2 L09759 [34] (48) <1->264 *
AV10S1 U32521 [6] (47,50) ° 233->421 *
TRAV27TRAV27 TRAV27*04 F 14q11.2 CM089104.1 IMGT000290 [26] 535870-536450
TRAV28TRAV28 TRAV28*01 P (10) 14q11.2 V28S1 AE000660 [5,7,21] 159044-159642
TRAV28TRAV28 TRAV28*02 P (11) 14q11.2 CM000676.2 IMGT000024 [13,23] MAP 543176-543774 CM089104.1 IMGT000290 [26] 542834-543432
TRAV29TRAV29/DV5 TRAV29/DV5*01 F 14q11.2
R αT αPr αR δT δPr δ
++++
 hADV29S1 AE000660 [5,7,21] 167277-167837 M15565 [25] #c 187-463 *
TRAV29TRAV29/DV5 TRAV29/DV5*02 F 14q11.2 Valpha21a S81645 [43] (51) c(st) 174-452 *
TRAV29TRAV29/DV5 TRAV29/DV5*03 P (52) 14q11.2 Valpha21c AJ245565 [43] 381-659 *
TRAV29TRAV29/DV5 TRAV29/DV5*04 F 14q11.2 CM000676.2 IMGT000024 [13,23] MAP 551446-552006 CM089104.1 IMGT000290 [26] 551140-551700
TRAV30TRAV30 TRAV30*01 F 14q11.2
R αT αPr αR δT δPr δ
+++
 V30S1 AE000660 [5,7,21] 172357-172955 S63879 [11] #g 351-621 *
E5 Z46642 [28] (44) #g 454-720 *
TRAV30TRAV30 TRAV30*02 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 Valphaw29 X58768 [36] (23) #c 95->361 *
TRAV30TRAV30 TRAV30*03 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 Valphaw29.n1 L06883 [37] (23) #c 64->330 *
TRAV30TRAV30 TRAV30*04 [F] 14q11.2 AV29S1 U32537 [6] (40) ° 256->485 *
TRAV30TRAV30 TRAV30*05 F 14q11.2 CM000676.2 IMGT000024 [13,23] MAP 556526-557124
TRAV30TRAV30 TRAV30*06 F 14q11.2 CM089104.1 IMGT000290 [26] 556220-556818
TRAV31TRAV31 TRAV31*01 P (12) 14q11.2 V31S1 AE000660 [5,7,21] 181202-181832
TRAV31TRAV31 TRAV31*02 P (13) 14q11.2 CM000676.2 IMGT000024 [13,23] MAP 565370-566000
TRAV31TRAV31 TRAV31*03 P (13) 14q11.2 CM089104.1 IMGT000290 [26] 565066-565696
TRAV32TRAV32 TRAV32*01 P (14) 14q11.2 V32S1 AE000660 [5,7,21] MAP 189490-190024 CM000676.2 IMGT000024 [13,23] 573659-574193
CM089104.1 IMGT000290 [26] 573353-573887
TRAV33TRAV33 TRAV33*01 P (15) 14q11.2 V33S1 AE000660 [5,7,21] MAP 194084-194678 DQ097933 224-818
CM000676.2 IMGT000024 [13,23] 578255-578849
CM089104.1 IMGT000290 [26] 577949-578543
TRAV33TRAV33 TRAV33*02 P (15) 14q11.2
R αT αPr αR δT δPr δ
+
 Z46653 [28] #g 202-470 *
TRAV34TRAV34 TRAV34*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V34S1 AE000660 [5,7,21] MAP 211462-212096 CM000676.2 IMGT000024 [13,23] 595631-596265
CM089104.1 IMGT000290 [26] 595329-595963
AV26S1 U32534 [6] (35) ° 288->522 *
Valphaw26 X58739 [36] (23) #c 70->339 *
TRAV35TRAV35 TRAV35*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V35S1 AE000660 [5,7,21] 225824-226442
TRAV35TRAV35 TRAV35*02 F 14q11.2
R αT αPr αR δT δPr δ
++
 CM089104.1 IMGT000290 [26] 609694-610312 AV25S1 U32533 [6] (30) ° 291->533 *
Valphaw25 X58738 [36] (23) #c 131->400 *
TRAV35TRAV35 TRAV35*03 P (16) 14q11.2 CM000676.2 IMGT000024 [13,23] MAP 609993-610611
TRAV36TRAV36/DV7 TRAV36/DV7*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 hADV36S1 AE000660 [5,7,21] 230689-231220
TRAV36TRAV36/DV7 TRAV36/DV7*02 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 Valphaw28 X61070 [35] #c 7-280 *
TRAV36TRAV36/DV7 TRAV36/DV7*03 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 Valphaw28 X58767 [36] (23) #c 109->378 *
TRAV36TRAV36/DV7 TRAV36/DV7*04 (F) 14q11.2
R αT αPr αR δT δPr δ
++++
 Vdelta7 Z46643 [28,36] (23) #c 87-357 * AV28S1 U32536 [6] (34) ° 203->456 *
TRAV36TRAV36/DV7 TRAV36/DV7*05 F 14q11.2 CM000676.2 IMGT000024 [13,23] 614859-615390 CM089104.1 IMGT000290 [26] 614560-615091
TRAV37TRAV37 TRAV37*01 P (17) 14q11.2 V37S1 AE000661 [5,7,21] MAP 18598-19113 CM000676.2 IMGT000024 [13,23] 653846-654399
CM089104.1 IMGT000290 [26] 653542-654095
TRAV38TRAV38-1 TRAV38-1*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V38S1 AE000661 [5,7,21] MAP 24820-25451 Valpha14.1a D13074 [30] (23) #c 61->339 *
CM000676.2 IMGT000024 [13,23] 660068-660699
TRAV38TRAV38-1 TRAV38-1*02 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 VA14.2 M64355 [4] (23) #c 94-373 *
TRAV38TRAV38-1 TRAV38-1*03 F 14q11.2
R αT αPr αR δT δPr δ
++
 CM089104.1 IMGT000290 [26] 659764-660395 M95394 [24] #c 35-317 *
TRAV38TRAV38-1 TRAV38-1*04 (F) 14q11.2
R αT αPr αR δT δPr δ
++
 Valpha14.n1 L06880 [37] (23) #c 61->339 *
TRAV38TRAV38-2/DV8 TRAV38-2/DV8*01 F 14q11.2
R αT αPr αR δT δPr δ
+++
 hADV38S2 AE000661 [5,7,21] MAP 34000-34636 CM000676.2 IMGT000024 [13,23] 669248-669884
CM089104.1 IMGT000290 [26] 668958-669594
AV14S1 U32524 [6] (27) ° 180->330 *
Valpha14.2 X58158 [32] (53) 678->837 *
Valpha14.1 Z29614 [18] #c 103-388 *
Vdelta8 Z46644 [28] #g 330-618 *
TRAV39TRAV39 TRAV39*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V39S1 AE000661 [5,7,21] MAP 56905-57443 CM000676.2 IMGT000024 [13,23] 692151-692689
CM089104.1 IMGT000290 [26] 691865-692403
Valphaw27 X58740 [36] (23) #c 66->335 *
TRAV40TRAV40 TRAV40*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 Valpha31 X73521 [3] MAP 70-537 V40S1 AE000661 [5,7,21] 67888-68355
CM000676.2 IMGT000024 [13,23] 702587-703054
CM089104.1 IMGT000290 [26] 702852-703319
TRAV41TRAV41 TRAV41*01 F 14q11.2
R αT αPr αR δT δPr δ
++
 V41S1 AE000661 [5,7,21] MAP 73586-74128 CM000676.2 IMGT000024 [13,23] 708285-708827
CM089104.1 IMGT000290 [26] 708556-709098
Valpha15.1 M17662 [20] #c 67-334 *
AV19S1 U32528 [6] (54) ° 213->414 *
TRAV46TRAV46 TRAV46*01 P (18) 14q11.2 V41S1 AE000661 [5,7,21] MAP 151025-151291 * CM000676.2 IMGT000024 [13,23] 785753-786019 *
CM089104.1 IMGT000290 [26] 786000-786266 *
TRAVATRAVA TRAVA*01 P (19) 14q11.2 AE000659 [5,7,21] 46774-47277
TRAVATRAVA TRAVA*02 P (7) 14q11.2 CM000676.2 IMGT000024 [13,23] MAP 179527-180030 CM089104.1 IMGT000290 [26] 179174-179677
TRAVBTRAVB TRAVB*01 P (20) 14q11.2 AE000659 [5,7,21] 116852-117399
TRAVBTRAVB TRAVB*02 P (20) 14q11.2 CM000676.2 IMGT000024 [13,23] MAP 249599-250148 CM089104.1 IMGT000290 [26] 249258-249807
TRAVCTRAVC TRAVC*01 P (21) 14q11.2 AE000660 [5,7,21] MAP 38197-38484 * CM000676.2 IMGT000024 [13,23] 422022-422309 *
CM089104.1 IMGT000290 [26] 421684-421971 *
IMGT notes: ↑
  1. Deletion of one nucleotide in FR1-IMGT , leading to a frameshift
  2. first part of V-REGION before the repeat LTR/ERVK (MER11C) insertion
  3. STOP-CODON in L-PART1, STOP-CODON in V-REGION: position 26 and 41 and frameshift in V-REGION: deletion of 1 nt in FR3-IMGT
  4. Pseudogene due to the insertion of a 6-nucleotide insertion ggagga in the V-HEPTAMER motif (D. Scaviner, M-P. Lefranc, 11/01/2002). Following a query from Lindsay Grey Cowell (11/07/2003), the functionality of TRAV8-7*01, first assigned as functional in the "T cell Receptor FactsBook", was changed to ORF, then to P as no rearranged TRAV8-7 sequences were found.
  5. pseudogene due to the insertion of a 6-nucleotide insertion ggagga in the V-HEPTAMER motif (D. Scaviner, M-P. Lefranc, 11/01/2002).
  6. no init-codon, atg replaced by acg
  7. frameshifts in V-REGION: several insertions and deletions
  8. frameshift in L-PART2, STOP-CODON in V-REGION: position 2 and 44 and frameshifts in V-REGION: several deletions
  9. Probably frameshift in L-PART1, FR1-IMGT and FR2-IMGT, but undefined positions
  10. because frameshift in FR3-IMGT
  11. frameshift in V-REGION: deletion of 2 nt in FR3-IMGT
  12. Pseudogene because of several frameshifts in V-EXON
  13. frameshift in L-PART2, frameshift in V-REGION: deletion of 1 nt in FR3-IMGT
  14. Pseudogene because of frameshifts in V-REGION.
  15. frameshift in V-REGION: several insertions and deletions.
  16. STOP-CODON in V-REGION: position 39
  17. Pseudogene because of frameshift in CDR1-IMGT
  18. no L-PART1, frameshift in V-REGION: several insertions and deletions
  19. frameshift in V-REGION: several insertions and deletions
  20. frameshift in V-REGION: deletion of 1 nt in FR2-IMGT
  21. no L-PART1, frameshifts in V-REGION: several insertions and deletions
  22. V-REGION is partial: AA 96 to 104 are missing (partial FR3-IMGT), and no CDR3-IMGT.
  23. CDR3-IMGT is partial: only amino acid 105 is present.
  24. V-REGION is partial: AA 78 to 104 are missing (partial FR3-IMGT), and no CDR3-IMGT.
  25. V-REGION is partial: AA 68 to 104 are missing (partial FR3-IMGT), and no CDR3-IMGT.
  26. V-REGION is partial: AA 101 to 104 are missing (partial FR3-IMGT), and no CDR3-IMGT.
  27. V-REGION is partial: AA 56 to 104 are missing (partial CDR2-IMGT), no FR3-IMGT and no CDR3-IMGT.
  28. V-REGION is partial: AA 1 to 8 are missing (partial FR1-IMGT), and only amino acid 105 is present ( partial CDR3-IMGT).
  29. V-REGION is partial: AA 87 to 104 are missing (partial FR3-IMGT), and no CDR3-IMGT.
  30. V-REGION is partial: AA 97 to 104 are missing (partial FR3-IMGT), and no CDR3-IMGT.
  31. Due to several sequencing errors between nucleotides 1 and 30, this part of the sequence is not annotated and FR1-IMGT and CDR1-IMGT have not been assigned. As a consequence, V-REGION is partial.
  32. V-REGION is partial: AA 1 to 28 are missing (no FR1-IMGT, and partial CDR1-IMGT).
  33. insertion of repeat LTR/ERVK (MER11C) insertion of 1072 nt in the V-REGION
  34. V-REGION is partial: AA 100 to 104 are missing (partial FR3-IMGT), and no CDR3-IMGT.
  35. V-REGION is partial: AA 94 to 104 are missing (partial FR3-IMGT), and no CDR3-IMGT.
  36. V-REGION is partial: AA 1 to 8 are missing (partial FR1-IMGT).
  37. V-REGION is partial: AA 89 to 104 are missing (partial FR3-IMGT), and no CDR3-IMGT.
  38. V-REGION is partial: AA 84 to 104 are missing (partial FR3-IMGT), and no CDR3-IMGT.
  39. V-REGION is partial: AA 1 is missing (partial FR1-IMGT), and only amino acid 105 is present (CDR3-IMGT partial).
  40. V-REGION is partial: AA 93 to 104 are missing (partial FR3-IMGT), and no CDR3-IMGT.
  41. Rearranged CDR3-IMGT is partial.
  42. V-REGION is partial: AA 1 is missing (partial FR1-IMGT), and AA 104 is missing (partial FR3-IMGT, and no CDR3-IMGT).
  43. V-REGION is partial: AA 81 to 104 are missing (partial FR3-IMGT), and no CDR3-IMGT.
  44. TRAV19 (Z46641) and TRAV30 (Z46642) have been found rearranged to TRDD3 [29]. However the authors could not test their expression on the cell surface and did not give them a DV nomenclature.
  45. V-REGION is partial: no CDR3-IMGT.
  46. V-REGION is partial: AA 1 to 42 are missing (part ial FR2-IMGT), and no FR1-IMGT.
  47. Partial sequences which could not be assigned to a given allele.
  48. V-REGION is partial: AA 1 is missing (partial FR1-IMGT), and no CDR3-IMGT.
  49. V-REGION is partial: AA 84cto 104 are missing (partial FR3-IMGT), and no CDR3-IMGT.
  50. V-REGION is partial: AA 79 to 104 are missing (partial FR3-IMGT), and no CDR3-IMGT.
  51. This gene is a sterile transcript. It has been found with a leader L region and a germline V region. L-V-sequence is in germline configuration.
  52. DELETION of one nucleotide leading to a frameshift.
  53. V-REGION is partial: AA 59 to 104 are missing (partial CDR2-IMGT), no FR3-IMGT, and no CDR3-IMGT.
  54. V-REGION is partial: AA 85 to 104 are missing (partial FR3-IMGT), and no CDR3-IMGT.
IMGT references: ↑
  1. Baer R. et al., Complex rearrangements within the human J delta-C delta/J alpha-C alpha locus and aberrant recombination between J alpha segments, EMBO J, vol. 7, no. 6, 1988, pp. 1661-1668. PUBMED: 2971534
  2. Baer R. et al., Fusion of an immunoglobulin variable gene and a T cell receptor constant gene in the chromosome 14 inversion associated with T cell tumors, Cell, vol. 43, no. 3 Pt 2, 1985, pp. 705-713. DOI: 10.1016/0092-8674(85)90243-0
  3. Bernard O. et al., Molecular analysis of T-cell receptor transcripts in a human T-cell leukemia bearing a t(1;14) and an inv(7); cell surface expression of a TCR-beta chain in the absence of alpha chain, Leukemia, vol. 7, no. 10, 1993, pp. 1645-1653. PUBMED: 8412327
  4. Boitel B. et al., Preferential V beta gene usage and lack of junctional sequence conservation among human T cell receptors specific for a tetanus toxin-derived peptide: evidence for a dominant role of a germline-encoded V region in antigen/major histocompatibility complex recognition, J. Exp. Med, vol. 175, no. 3, 1992, pp. 765-777. DOI: 10.1084/jem.175.3.765
  5. Boysen C. et al., Analysis of the 1.1-Mb human alpha/delta T-cell receptor locus with bacterial artificial chromosome clones, Genome Res, vol. 7, no. 4, 1997, pp. 330-338. PUBMED: 9110172
  6. Boysen C. et al., Identifying DNA polymorphisms in human TCRA/D variable genes by direct sequencing of PCR products, Immunogenetics, vol. 44, no. 2, 1996, pp. 121-127. DOI: 10.1007/s002510050099
  7. Boysen C. et al., T-Cell Receptor Alpha Delta Locus Complete Nucleotide Sequence, Unpublished.
  8. Charmley P. et al., Polymorphism detection and sequence analysis of human T-cell receptor V alpha-chain-encoding gene segments, Immunogenetics, vol. 39, no. 2, 1994, pp. 138-145. DOI: 10.1007/BF00188617
  9. Cornelis F, Unpublished.
  10. Croce C.M. et al., Gene for alpha-chain of human T-cell receptor: location on chromosome 14 region involved in T-cell neoplasms, Science, vol. 227, no. 4690, 1985, pp. 1044-1047. PUBMED: 3919442
  11. Griesinger F. et al., Differentiation in mature T lymphoid leukemia cells is unstable and reversible to myeloid cells, without the involvement of a common stem cell, J. Immunol, vol. 147, no. 10, 1991, pp. 3336-3341. PUBMED: 1658145
  12. Guglielmi P. et al., Use of a variable alpha region to create a functional T-cell receptor delta chain, Proc. Natl. Acad. Sci. U.S.A, vol. 85, no. 15, 1988, pp. 5634-5638. DOI: 10.1073/pnas.85.15.5634
  13. Heilig R. et al., The DNA sequence and analysis of human chromosome 14, Nature, vol. 421, no. 6923, 2003, pp. 601-607. PUBMED: 12508121
  14. Hewitt C.R. et al., Major histocompatibility complex independent clonal T cell anergy by direct interaction of Staphylococcus aureus enterotoxin B with the T cell antigen receptor, J. Exp. Med, vol. 175, no. 6, 1992, pp. 1493-1499. DOI: 10.1084/jem.175.6.1493
  15. Hurley C.K. et al., Nonrandom T cell receptor usage in the allorecognition of HLA-DR1 microvariation, J. Immunol, vol. 150, no. 4, 1993, pp. 1314-1324. PUBMED: 8381833
  16. Ibberson M.R. et al., Genomic organization of the human T-cell receptor variable alpha (TCRAV) gene cluster, Genomics, vol. 28, no. 2, 1995, pp. 131-139. DOI: 10.1006/geno.1995.1123
  17. Ibberson M.R. et al., T-cell receptor variable alpha (TCRAV) polymorphisms in European, Chinese, South American, AfroCaribbean, and Gambian populations, Immunogenetics, vol. 47, no. 2, 1998, pp. 124-130. DOI: 10.1007/s002510050337
  18. Kalams S.A. et al., Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire, J. Exp. Med, vol. 179, no. 4, 1994, pp. 1261-1271. DOI: 10.1084/jem.179.4.1261
  19. Kimura N. et al., Sequences and repertoire of the human T cell receptor alpha and beta chain variable region genes in thymocytes, Eur. J. Immunol, vol. 17, no. 3, 1987, pp. 375-383. PUBMED: 3494611
  20. Klein M.H. et al., Diversity and structure of human T-cell receptor alpha-chain variable region genes, Proc. Natl. Acad. Sci. U.S.A, vol. 84, no. 19, 1987, pp. 6884-6888. DOI: 10.1073/pnas.84.19.6884
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