Provisional nomenclature (scaffolds only, no chromosome assembly).
Naked mole-rat (Heterocephalus glaber) TRB locus
- The Naked mole-rat (Heterocephalus glaber) TRB locus spans 359 kilobases (kb),
from 10 kb upstream of the most 5' gene in the locus, TRBV1 (F), to 10 kb
downstream of the most 3' gene in the locus, TRBV30 (F). Nevertheless, the distance between TRBV1 and TRBV4 is not known.
The Locus representation
encompasses 430 kb including the 5' borne MOXD2 and the 3' borne EPHB6.
- The Naked mole-rat (Heterocephalus glaber) TRB locus consists
of 33 TRBV genes belonging to 27 TRBV subgroups, 2 TRBD genes
belonging to 2 TRBD set, 12 TRBJ genes belonging to 2 TRBJ set, and
2 TRBC genes.
- The TRBV genes span 322
kilobases (kb), the TRBD genes span 14 kilobases
(kb), the TRBJ genes span 6087 bases (b) and
the TRBC genes span 11 kilobases (kb).
Clusters
- The TRBV genes are localized in 2 V-CLUSTER:
- the 5' V-CLUSTER, classically in 5' of the TRBD, TRBJ and
TRBC, includes 32 TRBV genes belonging to 26 subgroups (7 genes
are functional, 8 genes are ORF and 17 genes are pseudogenes).
- the 3' V-CLUSTER, downstream of the TRBC in inverted
orientation, includes 1 TRBV gene (functional).
- The TRBD, TRBJ and TRBC genes are localized in two
D-J-C-CLUSTER between the 5' V-CLUSTER and the 3' V-CLUSTER:
- the first D-J-C-CLUSTER, in 3' of the 5' V-CLUSTER,
includes 1 TRBD gene (functional), 5 TRBJ genes (3 genes are
functional and 2 gene are ORF) and 1 TRBC gene (functional).
The most C-proximal TRBJ gene, TRBJ1-6, being localized at
5051 kilobases in 5' of TRBC1.
- the second D-J-C-CLUSTER, in 5' of the 3' V-CLUSTER,
includes 1 TRBD gene (functional), 7 TRBJ genes (4 genes are
functional and 3 gene are ORF) and 1 TRBC gene (functional). The most C-proximal TRBJ gene,
TRBJ2-7, being localized at 8859 kilobases in 5' of TRBC2.
Bornes of the Naked mole-rat (Heterocephalus glaber) TRB locus
- MOXD2 (5' borne) has been identified 4 kb upstream of
TRBV1S1, the most 5' gene in the locus.
- EPHB6 (3' borne) has been identified 182 kb downstream of
TRBV30, the most 3' gene in the locus.
- Created:
- 25/05/2021
- Last updated:
- Thursday, 18-Nov-2021 21:05:45 CET
- Author:
- Maria Georga
