IMGT Repertoire (IG and TR)

Naked mole-rat (Heterocephalus glaber) TRD locus

The Naked mole-rat (Heterocephalus glaber) TRD locus. The orientation of the locus is reverse (REV).
The Naked mole-rat (Heterocephalus glaber) TRA/TRD locus spans 762 kilobases (kb), from 10 kb upstream of the most 5' gene in the locus, TRAV43-1 (F), to 10 kb downstream of the most 3' gene in the locus, TRAC (F). The Locus representation encompasses 800 kb including the 3' borne DAD1.
The Naked mole-rat (Heterocephalus glaber) TRD locus consists of 5 TRDV genes belonging to 5 TRDV subgroups, 3 TRDD, 4 TRDJ segments and 1 TRDC gene.
The TRDV genes span 294 kilobases (kb), the TRDJ genes span 113 kilobases (kb), the TRDD genes span 35 kilobases (kb), the TRDC genes span 6 kilobases (kb)

The TRDV genes are localized in 2 V-CLUSTER:
- the 5' V-CLUSTER, classically in 5' of the TRDD, TRDJ and TRDC, includes 12 TRDV genes belonging to 8 subgroups (4 genes are functional, 1 is ORF and 7 genes are pseudogene).
- the 3' V-CLUSTER, downstream of the TRDC in inverted orientation, includes 1 TRDV gene (ORF).
The TRDD, TRDJ and TRDC genes are localized in one D-J-C-CLUSTER between the 5' V-CLUSTER and the 3' V-CLUSTER:
- The CLUSTER includes 3 TRDD genes belonging to 2 subgroups functional, 4 TRDJ (1 gene is functional, 2 genes are ORF and 1 gene is pseudogene) and 1 TRDC functional.