IMGT Repertoire (IG and TR)

Naked mole-rat (Heterocephalus glaber) TRD locus on chromosome 2

The Naked mole-rat (Heterocephalus glaber) TRD locus on chromosome 2. The orientation of the locus is reverse (REV).
The Naked mole-rat (Heterocephalus glaber) TRA/TRD locus spans 1400 kilobases (kb), from 10 kb upstream of the most 5' gene in the locus, TRAV1-1 (F), to 10 kb downstream of the most 3' gene in the locus, TRAC (F). The Locus representation encompasses 1600 kb including the 5' borne OR10G3 and the 3' borne DAD1.
The Naked mole-rat (Heterocephalus glaber) TRD locus consists of 11 TRDV genes belonging to 7 TRDV subgroups, 3 TRDD, 4 TRDJ segments and 1 TRDC gene.
The TRDV genes span 985 kilobases (kb), the TRDJ genes span 19 kilobases (kb), the TRDD genes span 35 kilobases (kb), the TRDC genes span 1 kilobases (kb)

The TRDV genes are localized in 2 V-CLUSTER:
- the 5' V-CLUSTER, classically in 5' of the TRDD, TRDJ and TRDC, includes 10 TRDV genes belonging to 6 subgroups (4 genes are functional, 2 is ORF and 5 genes are pseudogene).
- the 3' V-CLUSTER, downstream of the TRDC in inverted orientation, includes 1 TRDV gene (ORF).
The TRDD, TRDJ and TRDC genes are localized in one D-J-C-CLUSTER between the 5' V-CLUSTER and the 3' V-CLUSTER:
- The CLUSTER includes 3 TRDD genes (2 genes are functional and 1 gene is ORF), 4 TRDJ (1 gene is functional, 2 genes are ORF and 1 gene is pseudogene) and 1 TRDC functional.

OR10G3 (5' borne) has been identified 26 bp upstream of TRAV1, the most 5' gene in the locus.
DAD1 (3' borne) has been identified 20 kb downstream of TRAC, the most 3' gene in the locus.