IMGT Scientific chart

Correspondence between V numberings

IMGT unique numbering for V-DOMAIN and V-LIKE-DOMAIN
Correspondence between the IMGT unique Lefranc numbering and the different Kabat numberings (vertical display of examples) 1997
Correspondence between the IMGT unique Lefranc numbering and the different numberings (horizontal display) 1998
IMGT unique numbering (Lefranc) and structural correspondence for the different CDR-IMGT lengths with the diverse Kabat/Chothia numberings and CDR/loop delimitations (horizontal display per locus) 2008

Correspondence between numberings for CDR of different lengths (horizontal display)

Click here for:

CDR3-IMGT

This table displays the correspondence between the IMGT unique Lefranc numbering [1], Kabat [2] and Chothia [3-5] numberings for CDR3 of different lengths, with gaps indicated by dashes. For a table showing the same CDR3 amino acid numberings but without gaps, and therefore without correspondence, click here.

Asterisks indicate positions for which it is not possible to make changes from one numbering to the other, automatically [1].
Brackets indicate the limits of the CDR in each numbering.

For more information on the proteins, see Protein with known 3D structures-Identification and Colliers de Perles: Human Immunoglobulins.



IMGT                                                                                     CDR3-IMGT  
unique            C                                                                                                                             W
numbering [1]    104 [105  106  107  108  109  110  111  111.1  111.2  111.3  111.4  112.4  112.3  112.2  112.1  112  113  114  115  116  117] 118                   CDR        CDR3-
                                                                                                                                                                   length[2]   IMGT[1]
                                            *    *    *     *      *      *      *      *      *      *      *     *    *    *    *  
VH   [2]          92   93   94  [95   96   97   98   99   100    100A   100B   100C   100D   100E   100F   100G  100H 100I 100J 100K 101  102] 103                    19          21
                  92   93   94  [95   96   97   98   99   100    100A   100B   100C   100D   100E   100F   100G  100H 100I   -    -  101  102] 103                    17          19
                  92   93   94  [95   96   97   98   99   100    100A   100B   100C     -      -      -      -     -    -    -    -  101  102] 103                    11          13
                  92   93   94  [95   96   97   98   99   100    100A     -      -      -      -      -      -     -    -    -    -  101  102] 103                     9          11

                                                                                                                                                     H3 "canonical    H3        CDR3-     Example
                                                                                                                                                      structure"    length[5]  IMGT[1]  of proteins
                                                     *     *      *      *      *      *      *      *      *     *    *    *    * 
VH   [3]          92   93   94   95  [96   97   98   99   100    100a   100b   100c   100d   100e   100f   100g  100h 100i 100j 100k 101] 102  103                    17          21
                  92   93   94   95  [96   97   98   99   100    100a   100b   100c   100d   100e   100f   100g  100h 100i   -    -  101] 102  103                    15          19      Kol
                  92   93   94   95  [96   97   98   99   100    100a   100b   100c     -      -      -      -     -    -    -    -  101] 102  103                     9          13      McPC603
                  92   93   94   95  [96   97   98   99   100    100a     -      -      -      -      -      -     -    -    -    -  101] 102  103                     7          11      Newm






IMGT                                                   CDR3-IMGT     
unique            C                                                                                   F
numbering [1]    104 [105  106  107  108  109  110  111  111.1  112.1  112  113  114  115  116  117] 118                                                             CDR        CDR3-
                                                                                                                                                                   length[2]   IMGT[1]
                                           *    *    *     *      *     *    *    *    *
V-KAPPA [2]       88  [89   90   91   92   93   94   95   95A    95B   95C  95D  95E  95F   96   97]  98                                                              15          15
                  88  [89   90   91   92   93   94   95    -      -     -    -    -    -    96   97]  98                                                               9           9

                                                                                                                                                      L3 "canonical   L3        CDR3-     Example
                                                                                                                                                       structure"   length[5]  IMGT[1]  of proteins
                                           *    *    *     *      *     *    *    *    *    
V-KAPPA [3] [5]   88   89   90  [91   92   93   94   95    -      -     -    -    -    -    96]  97   98                                                   1,2         6           9      Rei, McPC603, J539






IMGT                                                   CDR3-IMGT   
unique            C                                                                                   F
numbering [1]    104 [105  106  107  108  109  110  111  111.1  112.1  112  113  114  115  116  117] 118                                                             CDR        CDR3-
                                                                                                                                                                   length[2]   IMGT[1]
                                           *    *    *     *      *     *    *    *    *                                 
V-LAMBDA [2]      88  [89   90   91   92   93   94   95   95A    95B   95C  95D  95E  95F   96   97]  98                                                              15          15
                  88  [89   90   91   92   93   94   95   95A    95B    -    -    -    -    96   97]  98                                                              11          11
                  88  [89   90   91   92   93   94   95    -      -     -    -    -    -    96   97]  98                                                               9           9

                                                                                                                                                      L3 "canonical   L3        CDR3-     Example
                                                                                                                                                       structure"   length[5]  IMGT[1]   of proteins
                                           *    *    *     *      *     *    *    *    *       
V-LAMBDA [3]      88   89   90  [91   92   93   93a  93b   94     95    -    -    -    -    96]  97   98                                                    2          8          11      Kol, Rhe
                  88   89   90  [91   92   93    -    -    94     95    -    -    -    -    96]  97   98                                                    1          6           9      Newm

                                           *    *    *      *     *     *    *    *    *       
V-LAMBDA [5]      88   89   90  [91   92   93   94   95    95a    95b   -    -    -    -    96]  97   98                                                    2          8          11      Kol, Rhe
                  88   89   90  [91   92   93   94   95     -      -    -    -    -    -    96]  97   98                                                    1          6           9      Newm

Colors are according to IMGT color menu for CDR-IMGT.

[1]	Lefranc, M.-P., The Immunologist, 7, 132-136 (1999).
[2]	Kabat, E.A. et al., In: Sequences of Proteins of Immunological Interest, NIH Publication, 91-3242 (1991).
[3]	Chothia, C. and Lesk, A.M., J. Mol. Biol., 196, 901-917 (1987).
[4]	Chothia, C. et al., Nature, 342, 877-883 (1989).
[5]	Al-Lazikani, B. et al., J. Mol. Biol., 273, 927-948 (1997).