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Correspondence between V numberings

Correspondence between the IMGT unique Lefranc numbering and the different Kabat numberings (vertical display of examples): Part 2 - T cell Receptor

Princeps table: Lefranc, M.-P., The Immunologist, 7, 132-136 (1999). pdf

Compared to the princeps papers [1-3], gaps in CDR1-IMGT and CDR2-IMGT are placed at the top of the loops [4]. IMGT numbering for rearranged CDR3-IMGT is described in IMGT unique numbering for V-DOMAIN and V-LIKE-DOMAIN [4].

FR-IMGT
and
CDR-IMGT		 IMGT
strands
and
loops		 TRBV TRAV TRDV TRGV
Human TRBV6-5 Human TRAV8-6 Human TRDV2 Human TRGV3
IMGT
numbering [3,4]		 Kabat
numbering [5]		 Nucleotides and amino acid translation IMGT
numbering [3,4]		 Kabat
numbering [5]		 Nucleotides and amino acid translation IMGT
numbering [3,4]		 Kabat
numbering [5]		 Nucleotides and amino acid translation IMGT
numbering [3,4]		 Kabat
numbering [5]		 Nucleotides and amino acid translation
FR1-IMGT A 1 1 aat ASN N 1 0 agc ALA A 1 00 gcc ALA A 1 01 tct SER S
2 2 gct ALA A 2 1 cag GLN Q 2 1 att ILE I 2 00 tcc SER S
3 3 ggt GLY G 3 2 tct SER S 3 2 gag GLU E 3 1 aac ASN N
4 4 gtc VAL V 4 3 gtg VAL V 4 3 ttg LEU L 4 2 ttg LEU L
5 5 act THR T 5 4 acc THR T 5 4 gtg VAL V 5 3 gaa GLU E
6 6 cag GLN Q 6 5 cag GLN Q 6 5 cct PRO P 6 4 ggg GLY G
7 7 acc THR T 7 6 ctt LEU L 7 6 gaa GLU E 7 5 aga ARG R
8 8 cca PRO P 8 7 gac ASP D 8 7 cac HIS H 8 6 acg THR T
9 9 aaa LYS K 9 8 agc SER S 9 8 caa GLN Q 9 7 aag LYS K
10 10 ttc PHE F 10 9 caa GLN Q 10 9 aca THR T 10 8 tca SER S
11 11 cag GLN Q 11 10 gtc VAL V 11 10 gtg VAL V 11 9 gtc VAL V
12 12 gtc VAL V 12 11 cct PRO P 12 11 cct PRO P 12 10 acc THR T
13 13 ctg LEU L 13 12 gtc VAL V 13 12 gtg VAL V 13 11 agg ARG R
14 14 aag LYS K 14 13 ttt PHE F 14 13 tca SER S 14 12 cag GLN Q
15 15 aca THR T 15 14 gaa GLU E 15 14 ata ILE I 15 13 act THR T
B 16 16 gga GLY G 16 15 gaa GLU E 16 15 ggg GLY G 16 14 ggg GLY G
17 17 cag GLN Q 17 16 gcc ALA A 17 16 gtc VAL V 17 15 tca SER S
18 18 agc SER S 18 17 cct PRO P 18 17 cct PRO P 18 16 tct SER S
19 19 atg MET M 19 18 gtg VAL V 19 18 gcc ALA A 19 17 gct ALA A
20 20 aca THR T 20 19 gag GLU E 20 19 acc THR T 20 18 gaa GLU E
21 21 ctg LEU L 21 20 ctg LEU L 21 20 ctc LEU L 21 19 atc ILE I
22 22 cag GLN Q 22 21 agg ARG R 22 21 agg ARG R 22 20 act THR T
23 23 tgt CYS C 23 22 tgc CYS C 23 22 tgc CYS C 23 21 tgc CYS C
24 24 gcc ALA A 24 23 aac ASN N 24 23 tcc SER S 24 22 gat ASP D
25 25 cag GLN Q 25 24 tac TYR Y 25 24 atg MET M 25 23 ctt LEU L
26 26 gat ASP D 26 25 tca SER S 26 25 aaa LYS K 26 24 act THR T
CDR1-IMGT BC 27 27 atg MET M 27 26 tcg SER S 27 26 gga GLY G 27 25 gta VAL V
28 28 aac ASN N 28 27 tct SER S 28 27 gaa GLU E 28 26 aca THR T
29 29 cat HIS H 29 28 gtt VAL V 29 28 gcg ALA A 29 27 aat ASN N
30 * --- --- - 30 * --- --- - 30 29 atc ILE I 30 * --- --- -
31 * --- --- - 31 * --- --- - 31 * --- --- - 31 * --- --- -
32 * --- --- - 32 * --- --- - 32 * --- --- - 32 * --- --- -
33 * --- --- - 33 * --- --- - 33 * --- --- - 33 * --- --- -
34 * --- --- - 34 * --- --- - 34 * --- --- - 34 * --- --- -
35 * --- --- - 35 * --- --- - 35 *30 ggt GLY G 35 * --- --- -
36 * --- --- - 36 *29 tca SER S 36 *31 aac ASN N 36 *28 acc THR T
37 *30 gaa GLU E 37 *30 gtg VAL V 37 *32 tac TYR Y 37 *29 ttc PHE F
38 *31 tac TYR Y 38 *31 tat TYR Y 38 *33 tat TYR Y 38 *30 tac TYR Y
FR2-IMGT C 39 32 atg MET M 39 32 ctc LEU L 39 34 atc ILE I 39 33 atc ILE I
40 33 tcc SER S 40 33 ttc PHE F 40 34A aac ASN N 40 34 cac HIS H
41 34 tgg TRP W 41 34 tgg TRP W 41 35 tgg TRP W 41 35 tgg TRP W
42 35 tat TYR Y 42 35 tat TYR Y 42 36 tac TYR Y 42 36 tac TYR Y
43 36 cga ARG R 43 36 gtg VAL V 43 37 agg ARG R 43 37 cta LEU L
44 37 caa GLN Q 44 37 caa GLN Q 44 38 aag LYS K 44 38 cac HIS H
45 38 gac ASP D 45 38 tac TYR Y 45 39 acc THR T 45 39 cag GLN Q
46 39 cca PRO P 46 39 ccc PRO P 46 40 caa GLN Q 46 40 gag GLU E
C' 47 40 ggc GLY G 47 40 aac ASN N 47 41 ggt GLY G 47 41 ggg GLY G
48 41 atg MET M 48 41 caa GLN Q 48 42 aac ASN N 48 42 aag LYS K
49 42 ggg GLY G 49 42 gga GLY G 49 43 aca THR T 49 43 gcc ALA A
50 43 ctg LEU L 50 43 ctc LEU L 50 44 atc ILE I 50 44 cca PRO P
51 44 agg ARG R 51 44 cag GLN Q 51 45 act THR T 51 45 cag GLN Q
52 45 ctg LEU L 52 45 ctt LEU L 52 46 ttc PHE F 52 46 cgt ARG R
53 46 att ILE I 53 46 ctc LEU L 53 47 ata ILE I 53 47 ctt LEU L
54 47 cat HIS H 54 47 ctg LEU L 54 48 tac TYR Y 54 48 ctg LEU L
55 48 tac TYR Y 55 48 aag LYS K 55 49 cga ARG R 55 49 tac TYR Y
CDR2-IMGT C'C" 56 49 tca SER S 56 *49 tat TYR Y 56 50 gaa GLU E 56 50 tat TYR Y
57 50 gtt VAL V 57 *50 tta LEU L 57 51 aag LYS K 57 51 gac ASP D
58 51 ggt GLY G 58 *51 tca SER S 58 * --- --- - 58 52 gtc VAL V
59 * --- --- - 59 *52 gga GLY G 59 * --- --- - 59 53 tcc SER S
60 * --- --- - 60 * --- --- - 60 * --- --- - 60 * --- --- -
61 * --- --- - 61 * --- --- - 61 * --- --- - 61 * --- --- -
62 * --- --- - 62 *53 tcc SER S 62 * --- --- - 62 *54 acc THR T
63 *52 gct ALA A 63 *54 acc THR T 63 * --- --- - 63 *55 gca ALA A
64 *53 ggt GLY G 64 *55 ctg LEU L 64 * --- --- - 64 *56 agg ARG R
65 *54 atc ILE I 65 *56 gtt VAL V 65 *52 gac ASP D 65 *57 gat ASP D
FR3-IMGT C" 66 55 act THR T 66 *57 gaa GLU E 66 *53 atc ILE I 66 *58 gtg VAL V
67 56 gac ASP D 67 *58 agc SER S 67 *54 tat TYR Y 67 *59 ttg LEU L
68 57 caa GLN Q 68 *59 atc ILE I 68 *55 ggc GLY G 68 *60 gaa GLU E
69 58 gga GLY G 69 * --- --- - 69 *56 cct PRO P 69 *61 tca SER S
70 59 gaa GLU E 70 * --- --- - 70 *57 ggt GLY G 70 *62 gga GLY G
71 60 gtc VAL V 71 * --- --- - 71 *57A ttc PHE F 71 *63 ctc LEU L
72 61 ccc PRO P 72 * --- --- - 72 *57B aaa LYS K 72 *64 agt SER S
73 *62 --- --- - 73 * --- --- - 73 *57C --- --- - 73 64A cca PRO P
74 *63 aat ASN N 74 *60 aac ASN N 74 58 gac ASP D 74 *65 gga GLY G
D 75 *64 ggc GLY G 75 61 ggt GLY G 75 59 aat ASN N 75 *66 aag LYS K
76 65 tac TYR Y 76 62 ttt PHE F 76 60 ttc PHE F 76 *67 tat TYR Y
77 66 aat ASN N 77 63 gag GLU E 77 61 caa GLN Q 77 *68 tat TYR Y
78 67 gtc VAL V 78 64 gct ALA A 78 62 ggt GLY G 78 *69 act THR T
79 68 tcc SER S 79 65 gaa GLU E 79 63 gac ASP D 79 *70 cat HIS H
80 69 aga ARG R 80 66 ttt PHE F 80 64 att ILE I 80 *71 aca THR T
81 70 tca SER S 81 67 aac ASN N 81 65 gat ASP D 81 *72 ccc PRO P
82 --- --- - 82 68 aag LYS K 82 66 att ILE I 82 * --- --- -
83 71 acc THR T 83 69 agt SER S 83 67 gca ALA A 83 73 agg ARG R
84 72 aca THR T 84 70 caa GLN Q 84 68 aag LYS K 84 74 agg ARG R
E 85 73 gag GLU E 85 71 act THR T 85 69 aac ASN N 85 75 tgg TRP W
86 74 gat ASP D 86 72 tcc SER S 86 70 ctg LEU L 86 76 agc SER S
87 75 ttc PHE F 87 73 ttc PHE F 87 71 gct ALA A 87 77 tgg TRP W
88 76 ccg PRO P 88 74 cac HIS H 88 72 gta VAL V 88 78 ata ILE I
89 77 ctc LEU L 89 75 ttg LEU L 89 73 ctt LEU L 89 79 ttg LEU L
90 78 agg ARG R 90 76 agg ARG R 90 74 aag LYS K 90 80 aga ARG R
91 79 ctg LEU L 91 77 aaa LYS K 91 75 ata ILE I 91 81 ctg LEU L
92 80 ctg LEU L 92 78 ccc PRO P 92 76 ctt LEU L 92 82 caa GLN Q
93 81 tcg SER S 93 79 tca SER S 93 77 gca ALA A 93 83 aat ASN N
94 82 gct ALA A 94 80 gtc VAL V 94 78 cca PRO P 94 84 cta LEU L
95 83 gct ALA A 95 81 cat HIS H 95 79 tca SER S 95 85 att ILE I
96 84 ccc PRO P 96 82 ata ILE I 96 80 gag GLU E 96 86 gaa GLU E
F 97 85 tcc SER S 97 83 agc SER S 97 81 aga ARG R 97 87 aat ASN N
98 86 cag GLN Q 98 84 gac ASP D 98 82 gat ASP D 98 88 gat ASP D
99 87 aca THR T 99 85 acg THR T 99 83 gaa GLU E 99 89 tct SER S
100 88 tct SER S 100 86 gct ALA A 100 84 ggg GLY G 100 90 ggg GLY G
101 89 gtg VAL V 101 87 gag GLU E 101 85 tct SER S 101 91 gtc VAL V
102 90 tac TYR Y 102 88 tac TYR Y 102 86 tac TYR Y 102 92 tat TYR Y
103 91 ttc PHE F 103 89 ttc PHE F 103 87 tac TYR Y 103 93 tac TYR Y
104 92 tgt CYS C 104 90 tgt CYS C 104 88 tgt CYS C 104 94 tgt CYS C
germline CDR3-IMGT 105 93 gcc ALA A 105 91 gct ALA A 105 89 gcc ALA A 105 95 gcc ALA A
106 94 agc SER S 106 92 gtg VAL V 106 90 tgt CYS C 106 96 acc THR T
107 95 agt SER S 107 93 agt SER S 107 91 gac ASP D 107 97 tgg TRP W
108 96 tat TYR Y 108 92 acc THR T 108 98 gac ASP D
109 97 --- --- - 109 99 agg ARG R
IMGT notes:

For each V-REGION group, one germline sequence is shown with, on the left hand side of each column, the IMGT unique numbering (in bold) defined by Marie-Paule Lefranc [1,2] and the corresponding numbering according to Kabat et al. [5].

Gaps (unoccupied positions) are shown with dashes.
Asteriks (*) indicate positions for which it is not possible to make changes from one numbering to the other, automatically.

Colors of amino acids are according to IMGT Color menu for sequence alignments.

For IMGT Colliers de Perles of the germline sequences (V-REGION) of this table in the IMGT unique numbering, click on the following V-GENE names. Lengths of the CDR1-IMGT, CDR2-IMGT and germline CDR3-IMGT are shown between brackets, separated by dots.

The IMGT unique numbering and IMGT Colliers de Perles for IG and TR V-DOMAIN (V-J-REGION and V-D-J-REGION) of all species are available in IMGT/3Dstructure-DB and IMGT/2Dstructure-DB.

IMGT References:
[1] Lefranc, "Unique database numbering system for immunogenetics analysis", Immunology Today, 18, 509 (1997). PMID: 9386342
[2] Lefranc, M.-P. "IMGT Locus on Focus: A new section of Experimental and Clinical Immunogenetics", Exp. Clin. Immunogenet., 15, 1-7 (1998). PMID: 9619395 pdf
[3] Lefranc, M.-P., "The IMGT unique numbering for immunoglobulins, T cell Receptors and Ig-like domains", The Immunologist, 7, 132-136 (1999). pdf
[4] Lefranc, M.-P. et al., Dev. Comp. Immunol., 27, 55-77 (2003). PMID: 12477501 pdf with permission from Elsevier
[5] Kabat et al., "Sequences of Proteins of Immunological Interest", NIH Publication, 91-3242 (1991).
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