• Fct: FUNCTIONALITY
  • F: Functional
  • P: Pseudogene
  • ORF: Open Reading Frame
• R: Rearranged
• T: Transcribed
• Pr: Translated into protein

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

Click on:

• IMGT gene name to get the corresponding IMGT/GENE-DB entry,
• IMGT allele name to see the corresponding Alignments of alleles,
• accession number to get the corresponding IMGT/LIGM-DB entry.

All the IGHV genes are in a fully sequenced contig which comprises the following accession numbers:

• AB019437 (200000 bp): IGHV(III)-82 to IGHV(II)-60-1
• AB019438 (200000 bp): IGHV3-60 to IGHV4(II)-40-1
• AB019439 (200000 bp): IGHV7-40 to IGHV3-21
• AB019440 (200000 bp): IGHV(II)-20-1 to IGHV2-5
• AB019441 (157090 bp): IGHV4-4 to IGHV6-1

Gene content of these accession numbers are shown in IMGT/LocusView

Individual gene sequences from these contigs were previously published [26] and are listed in the table below. Forty seven of these sequences are IMGT Reference sequences.

Click here for the Correspondence between nomenclatures.

The 7 human (Homo sapiens) IGHV subgroups form three clans (Figure IGHV clans). One additional clan only contains one pseudogene. Clans comprise, respectively:

• clan I: IGHV1, IGHV5 and IGHV7 subgroup genes
• clan II: IGHV2, IGHV4 and IGHV6 subgroup genes
• clan III: IGHV3 subgroup genes

IGHV genes are designated by a number for the subgroup, followed by a dash and a number for the localization from 3' to 5' in the locus.
IGHV genes which had a provisional nomenclature (number for the subgroup, followed by a dash and a small letter) [12,51] have now all been localized in the IGH locus.
The sequences previously designated as IGHV1-e have been shown to correspond to alleles IGHV1-69*06 and IGHV1-69*07. The sequences previously designated as IGHV3-g have been shown to correspond to allele IGHV3-71*01.
The sequences previously designated as IGHV1-c, IGHV1-f, IGHV3-d, IGHV3-h, IGHV4-b and IGHV5-a have been assigned respectively to the definitive IMGT gene names IGHV1-38-4, IGHV1-69-2, IGHV3-38-3, IGHV3-69-1, IGHV4-38-2 and IGHV5-10-1.