IMGT Repertoire (IG and TR)

Locus representation: House mouse (Mus musculus) IGH

House mouse (Mus musculus) IGH locus on chromosome 12 (12F2) strain C57BL/6

The orientation of the house mouse (Mus musculus) IGH locus on the chromosome 12 (12F2) strain C57BL/6 is reverse (REV).

Locus representation mouse IGH

Legend:
Colors are according to IMGT color menu for genes.
The boxes representing the genes are not to scale. Exons are not shown.
A double slash // indicates a gap in genome assembly. Distances in bp (base pair) or in kb (kilobase) associated with a double slash are taken into account in the length of the lines and included in the numbers displayed at the right end of the lines.
A dotted line ... indicates the distance in kb (kilobase) between the locus and its bornes (5' borne and the most 5' gene in the locus and/or 3' borne and the most 3' gene in the locus) on the top and bottom lines, respectively. These distances are not represented at scale and/or are not included in IMGT-LOCUS-UNIT and may not be included in the numbers displayed at the right ends of these two lines .

SWITCH sequences are represented by a filled circle upstream of the IGHC genes.

The Mouse (Mus musculus) IGHV genes belong to 16 subgroups (Gene tables: Mouse IGHV) which are part of three clans (Figure IGHV clans). Clans comprise, respectively:

  • clan I: IGHV1, IGHV9; IGHV14 and IGHV15 subgroup genes and one pseudogene IGHV(I)
  • clan II: IGHV2, IGHV3, IGHV8 and IGHV12 subgroup genes and pseudogenes IGHV(II)
  • clan III: IGHV4, IGHV5, IGHV6, IGHV7, IGHV10, IGHV11, IGHV13 and IGHV16 subgroup genes and pseudogenes IGHV(III).

Locus representation with only the functional genes: house mouse (Mus musculus) IGH

Locus representation mouse IGH

* When needed, indicate the presence of allele(s) with another functionality: see above house mouse (Mus musculus) IGH locus

Zoom for IGHD and IGHJ genes

zoom

IMGT references:
 IGHV genes
  1. [1] Crews, S. et al., Cell, 25, 59-66 (1981).
  2. [2] Brodeur, P.H. and Riblet, R., Eur. J. Immunol. 14, 922-930 (1984).
  3. [3] Winter, E. et al., EMBO J., 4, 2861-2867 (1985).
  4. [4] Brodeur, P.H. et al., J. Exp. Med., 168, 2261-2278 (1988).
  5. [5] Kofler, R. et al., J. Immunol., 140, 4031-4034 (1988).
  6. [6] Pennell, C.A. et al., Eur. J. Immunol., 19, 2115-2121 (1989).
  7. [7] Tutter, A. et al., J. Immunol., 147, 3215-3223 (1991).
  8. [8] Kofler, R. et al., Immunol. Rev., 128, 5-21 (1992).
  9. [9] Sims, M.J. et al., J. Immunol., 149, 1642-1648 (1992).
  10. [10] Sheehan, K.M. et al., J. Immunol., 151, 5364-5375 (1993).
  11. [11] Mainville, C.A. et al., J. Immunol., 156, 1058-1046 (1996).
  12. [12] Almagro, J.C. et al., Mol. Immunol., 34, 119-1214 (1997).
IGHD genes
  1. [13] Kurosawa, Y. and Tonegawa, S., J. Exp. Med., 155, 201-218 (1982).
  2. [14] Woods, C. and Tonegawa, S., Proc. Natl. Acad. Sci. USA 80, 3030-3034 (1983).
  3. [15] Feeney, A.J and Ribbet, R., Immunogenetics, 37, 217-221 (1993).
IGHJ genes
  1. [16] Early, P. et al., Cell, 19, 981-992 (1980).
  2. [17] Newell, N. et al., Science, 209, 1128-1132 (1980).
  3. [18] Sakano, H. et al., Nature, 286, 676-683 (1980).
IGHC genes
  1. [19] Edelman, G.M. et al., Proc. Natl. Acad. Sci. USA, 63, 78-85 (1969).
  2. [20] Honjo, T. and Kataoka,T., Proc. Natl Acad. Sci. USA, 75, 2140-2144 (1978).
  3. [21] Honjo, T. et al., Immunological Rev., 59, 33-67 (1981).
  4. [22] Yamawaki-Kataoka, Y. et al., Proc. Natl. Acad. Sci. USA, 79, 2623-2627 (1982).
  5. [23] Shimiza, A. et al., Cell, 28, 499-506 (1982).
IGH locus from the C57BL/6 genome sequencing
  1. [24] Riblet, R. In: Molecular Biology of B cells. Honjo, T., Alt, F.W. and Neuberger, M. eds, Elsevier Academic Press, London, pp 19-26 (2004).
  2. [25] Folch, G., Giudicelli, V., Jean, C., Ginestoux, C., Lefranc G. and Lefranc, M.-P. IMGT overview: the mouse immunoglobulin heavy IGH genes.19th International Mouse Genome Conference (IMGC), November 5-8, 2005, Strasbourg, France (2005)..
Created:
05/11/2005
Last updated:
22/09/2023
Authors:
Géraldine Folch