IMGT Repertoire (IG and TR)

Relative position (order) of a gene, in a locus from the 5' end of a locus to its 3' end. The number '0' indicates that the relative position is unknown.

Human (Homo sapiens) IGH locus

IMGT gene name	Functionality	IMGT gene orientation in locus	IMGT gene order	Copy Number Variation (CNV)	Haplotypes



					Haplotype 1	Haplotype 2	Haplotype 3	Haplotype 4	Haplotype 5	Haplotype 6	Rearranged locus 1	Rearranged locus 2	Rearranged locus 3		Rearranged locus 4		Potential Haplotype 2 (1)		Rearranged locus 5	Rearranged locus 6	Rearranged locus 7

					IMGT locus ID: Homosap_IGH_1 Genome assembly: GRCh38.p12	IMGT locus ID: Homosap_IGH_2 Genome assembly: T2T-CHM13v2.0	IMGT locus ID: Homosap_IGH_3 Genome assembly: GRCh37.p13	IMGT locus ID: Homosap_IGH_4 Genome assembly: mHomSap3.mat	IMGT locus ID: Homosap_IGH_5 Genome assembly: mHomSap3.pat	IMGT locus ID: Homosap_IGH_6 Genome assembly: PGP1v1	IMGT locus ID: Homosap_IGH_7 Genome assembly: NA19240.pri.mat.f1_v2	IMGT locus ID: Homosap_IGH_8 Genome assembly: NA19240.alt.pat.f1_v2	IMGT locus ID: Homosap_IGH_9 Genome assembly: HG01243.alt.pat.f1		IMGT locus ID: Homosap_IGH_10 Genome assembly: HG01243.pri.mat.f1_v2		IMGT locus ID: Homosap_IGH_11 Genome assembly: HG005.pri.mat.f1_v2		IMGT locus ID: Homosap_IGH_12 Genome assembly: HG005.pri.pat.f1_v2	IMGT locus ID: Homosap_IGH_13 Genome assembly: Q100 hg002v1.0.1.mat	IMGT locus ID: Homosap_IGH_14 Genome assembly: Q100 hg002v1.0.1.pat
							IMGT locus ID: Homosap_IGH_3 Genome assembly: GRCh37.p13	IMGT locus ID: Homosap_IGH_4 Genome assembly: mHomSap3.mat	IMGT locus ID: Homosap_IGH_5 Genome assembly: mHomSap3.pat	IMGT locus ID: Homosap_IGH_6 Genome assembly: PGP1v1
													JAHEOY010000121.1 IMGT000173	JAHEOY010000024.1 IMGT000174	JAHEOX010000114.1 IMGT000175	JAHEOX010000206.1 IMGT000176	JAHEPN010000185.1 IMGT000197	JAHEPN010000015.1 IMGT000198	JAHEPO010000026.1 IMGT000199

IGHV1-NL1	P		0

IGHV3-NL1	F		0

IGHV7-NL1	P		0

IGHV(III)-82	P	direct	1		1	1	1	1	1	1		1			1		1		1	1	1

IGHV7-81	ORF	direct	2		2	2	2	2	2	2	2	2	2		2		2		2	2	2

IGHV4-80	P	direct	3		3	3	3	3	3	3	3	3	3		3		3		3	3	3

IGHV3-79	P	direct	4		4	4	4	4	4	4	4	4	4		4		4		4	4	4

IGHV(II)-78-1	P	direct	5		5	5	5	5	5	5	5	5	5		5		5		5	5	5

IGHV5-78	P	direct	6		6	6	6	6	6	6	6	6	6		6		6		6	6	6

IGHV7-77	N.d.	direct	7

IGHV(III)-76-1	P	direct	8		8	8	8	8	8	8	8	8	8		8		8		8	8	8

IGHV3-76	P	direct	9		9	9	9	9	9	9	9	9	9		9		9		9	9	9

IGHV3-75	P	direct	10		10	10	10	10	10	10	10	10	10		10		10		10	10	10

IGHV(II)-74-1	P	direct	11		11	11	11	11	11	11	11	11	11		11		11		11	11	11

IGHV3-74	F	direct	12		12	12	12	12	12	12	12	12	12		12		12		12	12	12

IGHV3-73	F	direct	13		13	13	13	13	13	13	13	13	13		13		13		13	13	13

IGHV3-72	F	direct	14		14	14	14	14	14	14	14	14	14		14		14		14	14	14

IGHV3-71	P	direct	15		15	15	15	15	15	15	15	15	15		15		15		15	15	15

IGHV2-70	F ORF	direct	16	CNV1-5prime	16	16	16	16	16	16	16	16	16		16		16		16	16	16

IGHV1-69D	F	direct	17	Homo sapiens IGH CNV1 IGHV(17-20)7(3F,4P)	17				17			17

IGHV1-68D	P	direct	17.1		17.1				17.1			17.1

IGHV(III)-67-4D	P	direct	17.2		17.2				17.2			17.2

IGHV(III)-67-3D	P	direct	17.3		17.3				17.3			17.3

IGHV1-69-2	F	direct	18		18				18			18

IGHV3-69-1	P	direct	19		19				19			19

IGHV2-70D	F	direct	20		20				20			20

IGHV1-69	(F) F	direct	21	CNV1-3prime	21	21	21	21	21	21	21	21	21		21		21		21	21	21

IGHV1-68	P	direct	22		22	22	22	22	22	22	22	22	22		22		21		22	22	22

IGHV(III)-67-4	P	direct	23		23	23	23	23	23	23	23	23	23		23		21		23	23	23

IGHV(III)-67-3	P	direct	24		24	24	24	24	24	24	24	24	24		24		21		24	24	24

IGHV(III)-67-2	P	direct	25		25	25	25	25	25	25	25	25	25		25		21		25	25	25

IGHV(II)-67-1	P	direct	26		26	26	26	26	26	26	26	26	26		26		21		26	26	26

SLC20A1P1 (GLVR1)		direct	27														21

IGHV1-67	P	direct	28		28	28	28	28	28	28	28	28	28		28		28		28	28	28

IGHV3-66	F	direct	29		29	29	29	29	29	29	29	29	29		29		29		29	29	29

IGHV(II)-65-1	P	direct	30		30	30	30	30	30	30	30	30	30		30		30		30	30	30

IGHV3-65	P	direct	31		31	31	31	31	31	31	31	31	31		31		31		31	31	31

IGHV3-64	F	direct	32		32	32	32	32	32	32	32	32	32		32		32		32	32	32

GOLGA4P3 (Golgin)	nr	direct	33

IGHV3-63	P	direct	34		34	34	34	34	34	34	34	34	34		34		34		34	34	34

IGHV(II)-62-1	P	direct	35		35	35	35	35	35	35	35	35	35		35		35		35	35	35

IGHV3-62	F P	direct	36		36	36	36	36	36	36	36	36	36		36		36		36	36	36

IGHV4-61	(F) F ORF	direct	37		37	37	37	37	37	37	37	37	37		37		37		37	37	37

IGHV(II)-60-1	P	direct	38		38	38	38	38	38	38	38	38	38		38		38		38	38	38

IGHV3-60	P	direct	39		39	39	39	39	39	39	39	39	39		39		39		39	39	39

IGHV4-59	(F) F	direct	40		40	40	40	40	40	40	40	40	40		40		40		40	40	40

IGHV1-58	(F) F	direct	41		41	41	41	41	41	41	41	41	41		41		41		41		41

IGHV3-57	P	direct	42		42	42	42	42	42	42	42	42	42		42		42		42		42

IGHV7-56	P	direct	43		43	43	43	43	43	43	43	43	43		43		43		43		43

IGHV4-55	P	direct	44		44	44	44	44	44	44	44	44	44		44		44		44		44

IGHV3-54	P	direct	45		45	45	45	45	45	45	45	45	45		45		45		45		45

IGHV(II)-53-1	P	direct	46		46	46	46	46	46	46	46	46	46		46		46		46		46

IGHV3-53	(F) F	direct	47		47	47	47	47	47	47	47	47	47		47		47		47		47

IGHV3-52	P	direct	48		48	48	48	48	48	48	48	48	48		48		48		48		48

IGHV(II)-51-2	P	direct	49		49	49	49	49	49	49	49	49	49		49		49		49		49

IGHV8-51-1	ORF P	direct	50		50	50	50	50	50	50	50	50	50		50		50		50		50

IGHV5-51	(F) F	direct	51		51	51	51	51	51	51	51	51	51		51		51		51		51

IGHV3-50	P	direct	52		52	52	52	52	52	52	52	52	52		52		52		52		52

IGHV(II)-49-1	P	direct	53		53	53	53	53	53	53	53	53	53		53		53		53		53

IGHV3-49	F	direct	54		54	54	54	54	54	54	54	54	54		54		54		54		54

IGHV3-48	F	direct	55		55	55	55	55	55	55	55	55	55		55		55		55		V-D-J rearrangement (55-187-196)

IGHV(III)-47-1	P	direct	56		56	56	56	56	56	56	56	56	56		56		56		56

IGHV3-47	P	direct	57		57	57	57	57	57	57	57	57	57		57		57		57

IGHV(II)-46-1	P	direct	58		58	58	58	58	58	58	58	58	58		58		58		58

IGHV1-46	F	direct	59		59	59	59	59	59	59	59	59	59		59		59		59

IGHV1-45	F	direct	60		60	60	60	60	60	60	60	60	60		60		60		60

IGHV(II)-44-2	P	direct	61		61	61	61	61	61	61	61	61	61		61		61		61

IGHV(IV)-44-1	P	direct	62		62	62	62	62	62	62	62	62	62		62		62		62

IGHV(III)-44	P	direct	63		63	63	63	63		63	63	63	63		63		63		62

IGHV(II)-43-1	P	direct	64		64	64	64	64		64	64	64	64		64		64		64

IGHV3-43	F	direct	65		65	65	65	65		65	65	65	65		65		65		65

IGHV3-42	P	direct	66		66	66	66	66		66	66	66	66		66		66		66

IGHV3-41	P	direct	67		67	67	67	67		67	67	67	67		67		67		67

IGHV(II)-40-1	P	direct	68		68	68	68	68		68	68	68	68		68		68		68

IGHV7-40	P	direct	69		69	69	69	69		69	69	69	69		69		69		69

IGHV4-39	(F) F	direct	70	CNV2-5prime	70	70	70	70		70	70	70	70		70		70		70

IGHV1-38-4	ORF	direct	71	Homo sapiens IGH CNV2 IGHV(71-80)10(2F,2O,6P)							71	71

IGHV(III)-38-1D	P	direct	72								72	72

IGHV3-38-3	ORF	direct	73								73	73

IGHV(III)-44D	P	direct	74						74		74	74

IGHV(II)-43-1D	P	direct	75						75		75	75

IGHV3-43D	F	direct	76						76		76	76

IGHV3-42D	P	direct	77						77		77	77

IGHV7-40D	P	direct	78						78		78	78

IGHV4-38-2	F	direct	79						79		79	79

IGHV(III)-38-1	P	direct	80		80	80	80	80	80	80	80	80	80		80		80		80	80

IGHV3-38	ORF	direct	81	CNV2-3prime	81	81	81	81	81	81	81	81	81		81		81		81	81

IGHV3-37	P	direct	82		82	82	82	82	82	82	82	82	82		82		82		82	82

IGHV3-36	P	direct	83		83	83	83	83	83	83	83	83	83		83		83		83	83

IGHV3-35	F ORF	direct	84		84	84	84	84	84	84	84	84	84		84		84		84	84

IGHV7-34-1	P	direct	85		85	85	85	85	85	85	85	85	85		85		85		85	85

IGHV4-34	F	direct	86	CNV3-5prime	86	86	86	86	86	86	86	86	86				86		86	86

IGHV3-33-2	P	direct	87	Homo sapiens IGH CNV3 IGHV(87-112)26(8F,16P,2RPI)	87	87	87	87	87	87	87	87	87				87		87	87

IGHV(II)-33-1	P	direct	88		88	88	88	88	88	88	88	88	88						88	88

IGHV3-33	F	direct	89		89	89	89	89	89	89		89	89						89	89

GOLGA4P1 (Golgin)	nr	direct	90

IGHV3-32	P	direct	91		91	91	91	91	91	91		91	91						91	91

IGHV(II)-31-1	P	direct	92			92	92	92	92	92		92	92							92

IGHV4-31	(F) F	direct	93			93	93	93	93	93		93	93							93

IGHV3-30-52	P	direct	94			94			94	94			94

IGHV(II)-30-51	P	direct	95			95			95	95			95

IGHV3-30-5	F	direct	96			96			96	96	96		96

IGHV3-30-42	P	direct	97			97			97	97	97		97

IGHV(II)-30-41	P	direct	98			98			98	98	98		98

IGHV4-30-4	(F) F	direct	99			99			99	99	99		99

IGHV3-30-33	P	direct	100			100			100	100	100	100	100							100

IGHV(II)-30-32	P	direct	101			101			101	101	101	101	101				101			101

IGHV3-30-3	F	direct	102			102			102	102	102	102	102				102			102

IGHV3-30-22	P	direct	103			103			103	103	103	103	103				103			103

IGHV(II)-30-21	P	direct	104		104	104			104	104	104	104	104				104			104

IGHV4-30-2	F	direct	105		105	105			105	105	105	105	105							105

IGHV4-30-1	F	direct	106																	106

IGHV3-30-2	P	direct	107		107	107	107	107	107	107	107	107	107			107				107

IGHV(II)-30-1	P	direct	108		108	108	108	108	108	108	108	108	108			108				108

IGHV3-30	(F) F	direct	109		109	109	109	109	109	109	109	109	V-D-J rearrangement (109-183-200)			109				109

GOLGA4P2 (Golgin)	nr	direct	110

IGHV3-29	P	direct	111		111	111	111	111	111	111	111	111				111				111

IGHV(II)-28-1	P	direct	112		112	112	112	112	112	112	112	112				112			112	112

IGHV4-28	F	direct	113	CNV3-3prime	113	113	113	113	113	113	113	113				113	113		113	113

IGHV7-27	P	direct	114		114	114	114	114	114	114	114	114				114	114		114	114

IGHV(II)-26-2	P	direct	115		115	115	115	115	115	115	115	115				115	115		115	115

IGHV(III)-26-1	P	direct	116		116	116	116	116	116	116	116	116				116	116		116	116

IGHV2-26	F	direct	117		117	117	117	117	117	117	117	117				117	117		117	117

IGHV(III)-25-1	P	direct	118		118	118	118	118	118	118	118	118				118	118		118	118

IGHV3-25	ORF P	direct	119		119	119	119	119	119	119	119	119				119	119		119	119

IGHV1-24	F	direct	120	CNV4-5prime	120	120	120	120	120	120	120	120				120	120		120	120

IGHV3-23D	F	direct	121	Homo sapiens IGH CNV4 IGHV(121-123)3(1F,2P)								121				121			121

IGHV(III)-22-2D	P	direct	122									122				122			122

IGHV(II)-22-1D	P	direct	123									123				123			123

IGHV3-23	F	direct	124	CNV4-3prime	124	124	124	124	124	124	124	124				124	124		124	124

IGHV(III)-22-2	P	direct	125		125	125	125	125	125	125	125	125				125	125		125	125

IGHV(II)-22-1	P	direct	126		126	126	126	126	126	126	126	126				126	126		126	126

IGHV3-22	P	direct	127		127	127	127	127	127	127	127	127				127	127		127	127

IGHV3-21	(F) F	direct	128		128	128	128	128	128	128	128	128				128	128		128	128

IGHV(II)-20-1	P	direct	129		129	129	129	129	129	129	129	129				129	129		129	129

IGHV3-20	F ORF	direct	130		130	130	130	130	130	130	130	130				130	130		130	130

IGHV3-19	P	direct	131		131	131	131	131	131	131	131	131				131	131		131	131

IGHV1-18	F	direct	132		132	132	132	132	132	132	132	132				132	132		132	132

SLC20A1P2	nr	direct	133

IGHV1-17	P	direct	134		134	134	134	134	134	134	134	134				134	134		134	134

IGHV(III)-16-1	P	direct	135		135	135	135	135	135	135	135	135				135	135		135	135

IGHV3-16	ORF	direct	136		136	136	136	136	136	136	136	136				136	136		136	136

IGHV(II)-15-1	P	direct	137		137	137	137	137	137	137	137	137				137	137		137	137

IGHV3-15	F	direct	138		138	138	138	138	138	138	138	138				138	138		V-D-J rearrangement (138-180-198)	138

IGHV1-14	P	direct	139		139	139	139	139	139	139	139	139				139	139			139

IGHV(III)-13-1	P	direct	140		140	140	140	140	140	140	140	140				140	140			140

IGHV3-13	F	direct	141		141	141	141	141	141	141	141	141			141	141		141

IGHV(II)-12-1	P	direct	141.1		141.1	141.1	141.1	141.1	141.1	141.1	141.1	141.1			141.1	141.1		141.1

IGHV1-12	P	direct	142		142	142	142	142	142	142	142	142			142	142		142

IGHV(III)-11-1	P	direct	143		143	143	143	143	143	143	143	143			143	143		143

IGHV3-11	F P	direct	144	CNV5-5prime	144	144	144	144	144	144	144	144			144	144		144

IGHV2-10	P	direct	145	Homo sapiens IGH CNV5 IGHV(145-149)5(4F,1P), split into:IGHV-e1 (145-147)3(2F,1P) and IGHV-e2 (148-149)2(2F)		145	145		145	145	145	145			145	145		145

IGHV3-9	F	direct	146			146	146		146	146	146	146			146	146		146

IGHV1-8	F	direct	147			147	147		147	147	147	147			147	147		147

IGHV5-10-1	F	direct	148		148			148										148

IGHV(III)-10-2	P	direct	148.1		148.1			148.1										148.1

IGHV3-64D	F	direct	149		149			149										149

IGHV3-7-2	P	direct	149.1		149.1			149.1										149.1

IGHV(II)-7-1	P	direct	149.2		149.2			149.2										149.2

IGHV3-7	(F) F	direct	150	CNV5-3prime	150	150	150	150	150	150	150	150			150	150		150

IGHV3-6	P	direct	151		151	151	151	151	151	151	151	151			151	151		151

IGHV(III)-5-2	P	direct	152		152	152	152	152	152	152	152	152			152	152		152

IGHV(III)-5-1	P	direct	153		153	153	153	153	153	153	153	153			153	153		153

IGHV2-5	F	direct	154	CNV6-5prime	154	154	154	154	154	154	V-D-J rearrangement (154-185-197)	154				154		154

IGHV7-4-1	F	direct	155	Homo sapiens IGH CNV6 IGHV(155)1(1F)	155	155			155	155		155			155	155		155

IGHV(II)-4-4	P	direct	155.1		155.1	155.1			155.1	155.1		155.1			155.1	155.1		155.1

IGHV4-4	(F) F	direct	156	CNV6-3prime	156	156	156	156	156	156		156			156	156		156

IGHV1-3	(F) F	direct	157		157	157	157	157		157		157			157	157		157

IGHV(III)-2-1	P	direct	158		158	158	158	158		158		158			158	158		158

IGHV1-2	F	direct	159		159	159	159	159	159	159		159			159	159		159

RPS8P1 (S8]	nr	direct	160

ADAM6 (MDC)	nr	direct	161

IGHV(II)-1-1	P	direct	162		162	162	162	162	162	162		162			162			162

IGHV6-1	F P	direct	163		163	163	163	163	163	163		163			163			163

FAM30A (KIAA0125)	nr	direct	164

IGHD1-1	F	direct	165		165	165	165	165	165	165		165			165			165

IGHD2-2	F	direct	166		166	166	166	166	166	166		166			D-J rearrangement (166-200)			166

IGHD3-3	F	direct	167		167	167	167		167	167		167						167

IGHD4-4	F	direct	168		168	168	168		168	168		168						168

IGHD5-5	F	direct	169		169	169	169		169	169		169						169

IGHD6-6	F	direct	170		170	170	170		170	170		170						170

IGHD1-7	F	direct	171		171	171	171		171	171		171						171

IGHD2-8	F	direct	172		172	172	172		172	172		172						172

IGHD3-9	F	direct	173		173	173	173	173	173	173		D-J rearrangement (173-200)						173

IGHD3-10	F	direct	174		174	174	174	174	174	174								174

IGHD4-11	ORF	direct	175		175	175	175	175	175	175								175

IGHD5-12	F	direct	176		176	176	176	176	176	176								176

IGHD6-13	F	direct	177		177	177	177	177	177	177								177

IGHD1-14	ORF	direct	178		178	178	178	178	178	178								178

IGHD2-15	F	direct	179		179	179	179	179	179	179								179

IGHD3-16	F	direct	180		180	180	180	180	180	180								180

IGHD4-17	F	direct	181		181	181	181	181	181	181								181

IGHD5-18	F ORF	direct	182		182	182	182	182	182	182								182

IGHD6-19	F	direct	183		183	183	183	183	183	183								183

IGHD1-20	F	direct	184		184	184	184	184	184	184								184

IGHD2-21	F	direct	185		185	185	185	185	185	185							185

IGHD3-22	F	direct	186		186	186	186	186	186	186							D-J rearrangement (186-196)

IGHD4-23	ORF	direct	187		187	187	187	187	187	187

IGHD5-24	ORF	direct	188		188	188	188	188	188	188

IGHD6-25	F	direct	189		189	189	189	189	189	189

IGHD1-26	F	direct	190		190	190	190	190	190	190

IGHJ1P	P	direct	191		191	191	191	191	191	191

IGHD7-27	F	direct	192		192	192	192	192	192	192

IGHJ1	F	direct	193		193	193	193	193	193	193

IGHJ2	F	direct	194		194	194	194	194	194	194

IGHJ2P	P	direct	195		195	195	195	195	195	195

IGHJ3	F	direct	196		196	196	196	196	196	196

IGHJ4	F	direct	197		197	197	197	197	197	197							197	197

IGHJ5	F	direct	198		198	198	198	198	198	198	198						198	198

IGHJ3P	P	direct	199		199	199	199	199	199	199	199						199	199	199

IGHJ6	F	direct	200		200	200	200	200	200	200	200						200	200	200	200

IGHM	F	direct	201		201	201	201	201	201	201		201				201		201	201	201

IGHD	F	direct	202	CNV7-5prime	202	202	202	202	202	202		202				202		202	202	202

IGHG3	F	direct	203	Homo sapiens IGH CNV7 IGHC(203-211)9(7F,1OP,1P)	203	203	203	203	203	203		203				203		203	203	203	203

IGHG1	(F) F	direct	204		204	204	204	204	204	204	204	204	204		204	204		204	204	204	204

IGHEP1	P	direct	205		205	205	205	205	205	205	205	205	205		205			205	205	205	205

IGHA1	F	direct	206		206	206	206	206	206	206		206	206		206			206	206	206	206

IGHGP	F ORF P	direct	207		207	207	207	207	207	207		207		207	207			207	207	207	207

IGHG2	F	direct	208		208	208	208	208	208	208		208		208	208			208	208	208	208

IGHG4A	F	direct	208.1			208.1								208.1						208.1	208.1

IGHG4	F	direct	209		209	209	209	209	209	209	209	209		209	209			209 (2)		209	209

IGHE	F	direct	210		210	210	210	210	210	210	210	210		210	210			210	210	210	210

IGHA2	F	direct	211		211	211	211	211	211	211	211	211		211	211			211	211	211	211

IMGT notes:

(1) Potential haplotype 2 because IGHV(II)-1-1 IGHV6-1, IGHD and IGHJ genes haven't been identified.
(2) This IGHG4 gene is 100% identical IGHG4A*02 and is a rare case of non-duplicated IGHG4 containing Val at position 309, first described in Brusco A et al., Eur J Immunogenet. (1998) 25:349–55. PMID: 9805657

More information:

See also:

Created:: 02/10/2015
Last updated:: 10/10/2024
Authors:: Maria Georga, Ariadni Papadaki, Géraldine Folch, Joumana Jabado-Michaloud, Imène Chentli, Véronique Giudicelli, and Sofia Kossida

IMGT Repertoire (IG and TR)

Locus gene order: human (Homo sapiens) IGH locus

Human (Homo sapiens) IGH locus