IMGT Repertoire (IG and TR)

Locus gene order: human (Homo sapiens) IGH locus

Relative position (order) of a gene, in a locus from the 5' end of a locus to its 3' end. The number '0' indicates that the relative position is unknown.

Human (Homo sapiens) IGH locus

IMGT gene nameFunctionalityIMGT gene orientation in locusIMGT gene orderCopy Number Variation (CNV)Haplotypes
Haplotype 1Haplotype 2Haplotype 3Haplotype 4Haplotype 5Haplotype 6Rearranged locus 1Rearranged locus 2Rearranged locus 3Rearranged locus 4Potential Haplotype 2 (1)
IMGT locus ID: Homosap_IGH_1
Genome assembly: GRCh38.p12
IMGT locus ID: Homosap_IGH_2
Genome assembly: T2T-CHM13v2.0
IMGT locus ID: Homosap_IGH_3
Genome assembly: GRCh37.p13
IMGT locus ID: Homosap_IGH_4
Genome assembly: mHomSap3.mat
IMGT locus ID: Homosap_IGH_5
Genome assembly: mHomSap3.pat
IMGT locus ID: Homosap_IGH_6
Genome assembly: PGP1v1
IMGT locus ID: Homosap_IGH_6
Genome assembly: NA19240.pri.mat.f1_v2
IMGT locus ID: Homosap_IGH_8
Genome assembly: NA19240.alt.pat.f1_v2
IMGT locus ID: Homosap_IGH_9
Genome assembly: HG01243.alt.pat.f1
IMGT locus ID: Homosap_IGH_10
Genome assembly: HG01243.pri.mat.f1_v2
IMGT locus ID: Homosap_IGH_11
Genome assembly: HG005.pri.mat.f1_v2
JAHEOY010000121.1
IMGT000173
JAHEOY010000024.1
IMGT000174
JAHEOX010000114.1
IMGT000175
JAHEOX010000206.1
IMGT000176
JAHEPN010000185.1
IMGT000197
JAHEPN010000015.1
IMGT000198
IGHV1-NL1P0
IGHV3-NL1F0
IGHV7-NL1P0
IGHV(III)-82Pdirect1111 1 1 1 111
IGHV7-81ORFdirect2 222 2 2 2 2 2 22 2
IGHV4-80Pdirect3 3 3 3 3 3 3 3 3 33 3
IGHV3-79Pdirect4 4 4 4 4 4 4 4 4 44 4
IGHV(II)-78-1Pdirect5 5 5 5 5 5 5 5 5 5 5 5
IGHV5-78Pdirect6 6 6 6 6 6 6 6 6 6 6 6
IGHV7-77N.d.direct7
IGHV(III)-76-1Pdirect8 8 8 8 8 8 8 8 8 8 8 8
IGHV3-76Pdirect9 9 9 9 9 9 9 9 9 9 9 9
IGHV3-75Pdirect10 10 10 10 10 10 10 10 10 10 10 10
IGHV(II)-74-1Pdirect11 11 11 11 11 11 11 11 11 11 11 11
IGHV3-74Fdirect12 12 12 12 12 12 12 12 12 1212 12
IGHV3-73Fdirect13 13 13 13 13 13 13 13 13 1313 13
IGHV3-72Fdirect14 14 14 14 14 14 14 14 14 1414 14
IGHV3-71Pdirect15 15 15 15 15 15 15 15 15 1515 15
IGHV2-70F ORFdirect16CNV1-5prime 16 16 16 16 16 16 16 16 1616 16
IGHV1-69DFdirect 17 Homo sapiens IGH CNV1
IGHV(17-20)7(3F,4P)
17 17 17
IGHV1-68DPdirect17.117.117.117.1
IGHV(III)-67-4DPdirect17.217.217.217.2
IGHV(III)-67-3DPdirect17.317.317.317.3
IGHV1-69-2Fdirect18181818
IGHV3-69-1Pdirect19191919
IGHV2-70DFdirect20202020
IGHV1-69(F) Fdirect21CNV1-3prime2121212121212121212121
IGHV1-68Pdirect222222222222222222222221
IGHV(III)-67-4Pdirect232323232323232323232321
IGHV(III)-67-3Pdirect242424242424242424242421
IGHV(III)-67-2Pdirect252525252525252525252521
IGHV(II)-67-1Pdirect262626262626262626262621
SLC20A1P1 (GLVR1)direct2721
IGHV1-67Pdirect282828282828282828282828
IGHV3-66Fdirect292929292929292929292929
IGHV(II)-65-1Pdirect303030303030303030303030
IGHV3-65Pdirect313131313131313131313131
IGHV3-64Fdirect323232323232323232323232
GOLGA4P3 (Golgin)nrdirect33
IGHV3-63Pdirect343434343434343434343434
IGHV(II)-62-1Pdirect353535353535353535353535
IGHV3-62F Pdirect363636363636363636363636
IGHV4-61(F) F ORFdirect373737373737373737373737
IGHV(II)-60-1Pdirect383838383838383838383838
IGHV3-60Pdirect393939393939393939393939
IGHV4-59(F) Fdirect404040404040404040404040
IGHV1-58(F) Fdirect414141414141414141414141
IGHV3-57Pdirect424242424242424242424242
IGHV7-56Pdirect434343434343434343434343
IGHV4-55Pdirect444444444444444444444444
IGHV3-54Pdirect454545454545454545454545
IGHV(II)-53-1Pdirect464646464646464646464646
IGHV3-53(F) Fdirect474747474747474747474747
IGHV3-52Pdirect484848484848484848484848
IGHV(II)-51-2Pdirect494949494949494949494949
IGHV8-51-1ORF Pdirect505050505050505050505050
IGHV5-51(F) Fdirect515151515151515151515151
IGHV3-50Pdirect525252525252525252525252
IGHV(II)-49-1Pdirect535353535353535353535353
IGHV3-49Fdirect545454545454545454545454
IGHV3-48Fdirect555555555555555555555555
IGHV(III)-47-1Pdirect565656565656565656565656
IGHV3-47Pdirect575757575757575757575757
IGHV(II)-46-1Pdirect585858585858585858585858
IGHV1-46Fdirect595959595959595959595959
IGHV1-45Fdirect606060606060606060606060
IGHV(II)-44-2Pdirect616161616161616161616161
IGHV(IV)-44-1Pdirect626262626262626262626262
IGHV(III)-44Pdirect6363636363636363636363
IGHV(II)-43-1Pdirect6464646464646464646464
IGHV3-43Fdirect6565656565656565656565
IGHV3-42Pdirect6666666666666666666666
IGHV3-41Pdirect6767676767676767676767
IGHV(II)-40-1Pdirect6868686868686868686868
IGHV7-40Pdirect6969696969696969696969
IGHV4-39(F) Fdirect70CNV2-5prime 70 70 70 70 70 70 70 707070
IGHV1-38-4ORFdirect71 Homo sapiens IGH CNV2
IGHV(71-80)10(2F,2O,6P)
7171
IGHV(III)-38-1DPdirect727272
IGHV3-38-3ORFdirect737373
IGHV(III)-44DPdirect74747474
IGHV(II)-43-1DPdirect75757575
IGHV3-43DFdirect76767676
IGHV3-42DPdirect77777777
IGHV7-40DPdirect78787878
IGHV4-38-2Fdirect79797979
IGHV(III)-38-1Pdirect808080808080808080808080
IGHV3-38ORFdirect81CNV2-3prime8181818181818181818181
IGHV3-37Pdirect828282828282828282828282
IGHV3-36Pdirect838383838383838383838383
IGHV3-35F ORFdirect848484848484848484848484
IGHV7-34-1Pdirect858585858585858585858585
IGHV4-34Fdirect86CNV3-5prime86868686868686868686
IGHV3-33-2Pdirect87 Homo sapiens IGH CNV3
IGHV(87-112)26(8F,16P,2RPI)
87878787878787878787
IGHV(II)-33-1Pdirect88888888888888888888
IGHV3-33Fdirect898989898989898989
GOLGA4P1 (Golgin)nrdirect90
IGHV3-32Pdirect919191919191919191
IGHV(II)-31-1Pdirect9292929292929292
IGHV4-31(F) Fdirect9393939393939393
IGHV3-30-52Pdirect9494949494
IGHV(II)-30-51Pdirect9595959595
IGHV3-30-5Fdirect969696969696
IGHV3-30-42Pdirect979797979797
IGHV(II)-30-41Pdirect989898989898
IGHV4-30-4(F) Fdirect999999999999
IGHV3-30-33Pdirect100100100100100100100
IGHV(II)-30-32Pdirect101101101101101101101101
IGHV3-30-3Fdirect102102102102102102102102
IGHV3-30-22Pdirect103103103103103103103103
IGHV(II)-30-21Pdirect104104104104104104104104104
IGHV4-30-2Fdirect105105105105105105105105
IGHV4-30-1Fdirect106
IGHV3-30-2Pdirect107107107107107107107107107107107
IGHV(II)-30-1Pdirect108108108108108108108108108108108
IGHV3-30(F) Fdirect109109109109109109109109109V-D-J rearrangement (109-183-200)109
GOLGA4P2 (Golgin)nrdirect110
IGHV3-29Pdirect111111111111111111111111111111
IGHV(II)-28-1Pdirect112112112112112112112112112112
IGHV4-28Fdirect113CNV3-3prime113113113113113113113113113113
IGHV7-27Pdirect114114114114114114114114114114114
IGHV(II)-26-2Pdirect115115115115115115115115115115115
IGHV(III)-26-1Pdirect116116116116116116116116116116116
IGHV2-26Fdirect117117117117117117117117117117117
IGHV(III)-25-1Pdirect118118118118118118118118118118118
IGHV3-25ORF Pdirect119119119119119119119119119119119
IGHV1-24Fdirect120CNV4-5prime120120120120120120120120120120
IGHV3-23DFdirect121 Homo sapiens IGH CNV4
IGHV(121-123)3(1F,2P)
121121
IGHV(III)-22-2DPdirect122122122
IGHV(II)-22-1DPdirect123123123
IGHV3-23Fdirect124CNV4-3prime124124124124124124124124124124
IGHV(III)-22-2Pdirect125125125125125125125125125125125
IGHV(II)-22-1Pdirect126126126126126126126126126126126
IGHV3-22Pdirect127127127127127127127127127127127
IGHV3-21(F) Fdirect128128128128128128128128128128128
IGHV(II)-20-1Pdirect129129129129129129129129129129129
IGHV3-20F ORFdirect130130130130130130130130130130130
IGHV3-19Pdirect131131131131131131131131131131131
IGHV1-18Fdirect132132132132132132132132132132132
SLC20A1P2nrdirect133
IGHV1-17Pdirect134134134134134134134134134134134
IGHV(III)-16-1Pdirect135135135135135135135135135135135
IGHV3-16ORFdirect136136136136136136136136136136136
IGHV(II)-15-1Pdirect137137137137137137137137137137137
IGHV3-15Fdirect138138138138138138138138138138138
IGHV1-14Pdirect139139139139139139139139139139139
IGHV(III)-13-1Pdirect140140140140140140140140140140140
IGHV3-13Fdirect141141141141141141141141141141141
IGHV(II)-12-1Pdirect141.1 141.1 141.1 141.1 141.1 141.1 141.1 141.1 141.1141.1141.1
IGHV1-12Pdirect142142142142142142142142142142142
IGHV(III)-11-1Pdirect143143143143143143143143143143143
IGHV3-11F Pdirect144CNV5-5prime144144144144144144144144144144
IGHV2-10Pdirect145 Homo sapiens IGH CNV5
IGHV(145-149)5(4F,1P), split into:IGHV-e1 (145-147)3(2F,1P) and IGHV-e2 (148-149)2(2F)
145145145145145145145145
IGHV3-9Fdirect146146146146146146146146146
IGHV1-8Fdirect147147147147147147147147147
IGHV5-10-1Fdirect148148148
IGHV(III)-10-2Pdirect148.1148.1148.1
IGHV3-64DFdirect149149149
IGHV3-7-2Pdirect149.1149.1149.1
IGHV(II)-7-1Pdirect149.2149.2149.2
IGHV3-7(F) Fdirect150CNV5-3prime150150150150150150150150150150
IGHV3-6Pdirect151151151151151151151151151151151
IGHV(III)-5-2Pdirect152152152152152152152152152152152
IGHV(III)-5-1Pdirect153153153153153153153153153153153
IGHV2-5Fdirect154CNV6-5prime154154154154154154V-D-J rearrangement (154-185-197)154154
IGHV7-4-1Fdirect155 Homo sapiens IGH CNV6
IGHV(155)1(1F)
155155155155155155155
IGHV(II)-4-2Pdirect155.1155.1155.1155.1155.1155.1155.1 155.1
IGHV4-4(F) Fdirect>156CNV6-3prime156156156156156156156156 156
IGHV1-3(F) Fdirect157157157157157157157157157 157
IGHV(III)-2-1Pdirect158158158158158158158158158 158
IGHV1-2Fdirect159159159159159159159159159 159
RPS8P1 (S8]nrdirect160
ADAM6 (MDC)nrdirect161
IGHV(II)-1-1Pdirect162162162162162162162162162
IGHV6-1F Pdirect163163163163163163163163163
FAM30A (KIAA0125)nrdirect164
IGHD1-1Fdirect165165165165165165165165165
IGHD2-2Fdirect166166166166166166166166D-J rearrangement (166-200)
IGHD3-3Fdirect167167167167167167167
IGHD4-4Fdirect168168168168168168168
IGHD5-5Fdirect169169169169169169169
IGHD6-6Fdirect170170170170170170170
IGHD1-7Fdirect171171171171171171171
IGHD2-8Fdirect172172172172172172172
IGHD3-9Fdirect173173173173173173173D-J rearrangement (173-200)
IGHD3-10Fdirect174174174174174174174
IGHD4-11ORFdirect175175175175175175175
IGHD5-12Fdirect176176176176176176176
IGHD6-13Fdirect177177177177177177177
IGHD1-14ORFdirect178178178178178178178
IGHD2-15Fdirect179179179179179179179
IGHD3-16Fdirect180180180180180180180
IGHD4-17Fdirect181181181181181181181
IGHD5-18F ORFdirect182182182182182182182
IGHD6-19Fdirect183183183183183183183
IGHD1-20Fdirect184184184184184184184
IGHD2-21Fdirect185185185185185185185
IGHD3-22Fdirect186186186186186186186
IGHD4-23ORFdirect187187187187187187187
IGHD5-24ORFdirect188188188188188188188
IGHD6-25Fdirect189189189189189189189
IGHD1-26Fdirect190190190190190190190
IGHJ1PPdirect191191191191191191191
IGHD7-27Fdirect192192192192192192192
IGHJ1Fdirect193193193193193193193
IGHJ2Fdirect194194194194194194194
IGHJ2PPdirect195195195195195195195
IGHJ3Fdirect196196196196196196196
IGHJ4Fdirect197197197197197197197
IGHJ5Fdirect198198198198198198198198
IGHJ3PPdirect199199199199199199199199
IGHJ6Fdirect200200200200200200200200
IGHMFdirect201201201201201201201201201201
IGHDFdirect202CNV7-5prime202202202202202202202202202
IGHG3Fdirect203 Homo sapiens IGH CNV7
IGHC(203-211)9(7F,1OP,1P)
203203203203203203203203203
IGHG1(F) Fdirect204204204204204204204204204204204204204
IGHEP1Pdirect205205205205205205205205205205205205
IGHA1Fdirect206206206206206206206206206206206
IGHGPF ORF Pdirect207207207207207207207207207207207
IGHG2Fdirect208208208208208208208208208208208
IGHG4AFdirect208.1 208.1 208.1
IGHG4Fdirect209209209209209209209209209209209209 (2)
IGHEFdirect210210210210210210210210210210210210
IGHA2Fdirect211211211211211211211211211211211211
IMGT notes:
  1. (1) Potential haplotype 2 because IGHV(II)-1-1 IGHV6-1, IGHD and IGHJ genes haven't been identified.
  2. (2) This IGHG4 gene is 100% identical IGHG4A*02 and is a rare case of non-duplicated IGHG4 containing Val at position 309, first described in Brusco A et al., Eur J Immunogenet. (1998) 25:349–55. PMID: 9805657
Created:
02/10/2015
Last updated:
13/06/2024
Authors:
Maria Georga, Ariadni Papadaki, Géraldine Folch, Joumana Jabado-Michaloud, Imène Chentli, Véronique Giudicelli, and Sofia Kossida