Cancer, Leucémie, Lymphome
Cancer, Leukemia, Lymphoma

Translocations and inversions

Overview

1. Genes involved in immunoglobulin (IG) or T cell receptor (TR) translocations
2. Chromosomal localizations of the genes (other than IG or TR) involved in the translocations
3. Chromosomal localizations of the human immunoglobulin (IG) and T cell receptor (TR) loci
4. Clinical entities with immunoglobulin (IG) or T cell receptor (TR) translocations

Details

• IGH: Human,Translocations & inversions involving the human IGH locus
• IGK: Human, Translocations involving the IGK locus
• IGL: Human, Translocations involving the IGL locus
• TRA: Human, Translocations & inversion involving the TRA locus
• TRB: Human, Translocations & inversion involving the TRB locus
• TRG: Human, Translocations & inversion involving the TRG locus
• TRD: Human, Translocations & inversion involving the TRD locus

IMGT Education

• Translocations chromosomiques et cancer
• Dérégulation moléculaire et cancer : prolifération, survie et inhibition de l'apoptose
• Les récepteurs à activité tyrosine kinase (RTKs) réarrangés dans les hémopathies malignes
• And more in IMGT Education...

CLL, Chronic Lymphocytic Leukemia

• Educational Workshop on Immunoglobulin Gene Analysis in Chronic Lymphocytic Leukemia, Uppsala, Sweden, June 14-15 (2007).
• ERIC, European Research Initiative on CLL.
• ERIC recommendations on IGHV gene mutational status analysis in chronic lymphocytic leukemia, Leukemia 21, 1-3 (2007).

ALL, acute lymphoblastic leukemia

• EuroMRD, European Consortium for Minimal Residual Disease (MRD), a division of ESLHO

External links and resources

• 7èmes Journées Scientifiques du Cancéropôle CLARA - Conférences (in English)
• ESLHO, European Scientific foundation for Laboratory Hemato Oncology
• EuroClonality, a division of ESLHO
• EuroFlow, a division of ESLHO
• The Mesothelium Cancer Alliance, Resources for Patients and their Families.
• Mesothelioma Explained
• Targeted therapy against human lung cancer in nude mice by high-affinity recombinant antimesothelin single-chain Fv immunotoxin
• LeGenD, Leukemia Gene Database
• Rapport de la commission d'orientation sur le cancer (Dossier de presse du 16 janvier 2003)
• WHO Classification of Tumours
• Melanoma Molecular Map Project (MMMP), interactive multidatabase dedicated to the translational research on melanoma/cancer (molecules > pathways > targeted drugs > clinical trials).
• And more in IMGT Bloc-notes